Chemokine receptor 4 targeted protein MRI contrast agent for early detection of liver metastases

Shanshan Tan; Hua Yang; Shenghui Xue; Jingjuan Qiao; Mani Salarian; Khan Hekmatyar; Yuguang Meng; Rao Mukkavilli; Fan Pu; Oluwatosin Y. Odubade; Wayne Harris; Yan Hai; Melinda L. Yushak; Vanessa M. Morales-Tirado; Pardeep Mittal; Phillip Z. Sun; David Lawson; Hans E. Grossniklaus; Jenny J. Yang

doi:10.1126/sciadv.aav7504

Research ArticleRESEARCH METHODS

Chemokine receptor 4 targeted protein MRI contrast agent for early detection of liver metastases

View ORCID ProfileShanshan Tan¹,
View ORCID ProfileHua Yang²,
Shenghui Xue³,
View ORCID ProfileJingjuan Qiao¹,
Mani Salarian¹,
Khan Hekmatyar⁴,
View ORCID ProfileYuguang Meng⁵,
View ORCID ProfileRao Mukkavilli⁶,
Fan Pu¹,
Oluwatosin Y. Odubade¹,
View ORCID ProfileWayne Harris⁷,
View ORCID ProfileYan Hai⁸,
Melinda L. Yushak⁷,
Vanessa M. Morales-Tirado⁹,*,
View ORCID ProfilePardeep Mittal¹⁰,
View ORCID ProfilePhillip Z. Sun⁵,
David Lawson⁷,
Hans E. Grossniklaus² and
View ORCID ProfileJenny J. Yang ¹,¹¹,†

¹Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
²Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA.
³InLighta Biosciences LLC, Atlanta, GA 30303, USA.
⁴Bioimaging Research Center, University of Georgia, Athens, GA 30602, USA.
⁵Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
⁶Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
⁷Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA.
⁸Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA.
⁹Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
¹⁰Department of Radiology and Imaging, Augusta University, Augusta, GA 30912, USA.
¹¹Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.

↵†Corresponding author. Email: jenny{at}gsu.edu

↵* Present address: AbbVie Bioresearch Center, 100 Research Dr., Worcester, MA 01605, USA.

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Science Advances 07 Feb 2020:
Vol. 6, no. 6, eaav7504
DOI: 10.1126/sciadv.aav7504

Shanshan Tan

1Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

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Hua Yang

2Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA.

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Shenghui Xue

3InLighta Biosciences LLC, Atlanta, GA 30303, USA.

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Jingjuan Qiao

1Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

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Mani Salarian

1Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

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Khan Hekmatyar

4Bioimaging Research Center, University of Georgia, Athens, GA 30602, USA.

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Yuguang Meng

5Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

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Rao Mukkavilli

6Department of Biology, Georgia State University, Atlanta, GA 30303, USA.

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Fan Pu

1Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

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Oluwatosin Y. Odubade

1Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

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Wayne Harris

7Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA.

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Yan Hai

8Department of Mathematics and Statistics, Georgia State University, Atlanta, GA 30303, USA.

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Melinda L. Yushak

7Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA.

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Vanessa M. Morales-Tirado

9Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, TN 38103, USA.

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Pardeep Mittal

10Department of Radiology and Imaging, Augusta University, Augusta, GA 30912, USA.

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Phillip Z. Sun

5Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.

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David Lawson

7Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322, USA.

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Hans E. Grossniklaus

2Department of Ophthalmology, Emory University, Atlanta, GA 30322, USA.

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Jenny J. Yang

1Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

11Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.

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For correspondence: jenny@gsu.edu

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Chemokine receptor 4 targeted protein MRI contrast agent for early detection of liver metastases

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