A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity

Munir Akkaya; Abhisheka Bansal; Patrick W. Sheehan; Mirna Pena; Alvaro Molina-Cruz; Lindsey M. Orchard; Clare K. Cimperman; Chen-Feng Qi; Philipp Ross; Takele Yazew; Daniel Sturdevant; Sarah L. Anzick; Girija Thiruvengadam; Thomas Dan Otto; Oliver Billker; Manuel Llinás; Louis H. Miller; Susan K. Pierce

doi:10.1126/sciadv.aaw6957

Research ArticleIMMUNOLOGY

A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity

View ORCID ProfileMunir Akkaya¹,*,
Abhisheka Bansal²,†,
View ORCID ProfilePatrick W. Sheehan¹,‡,
Mirna Pena¹,
View ORCID ProfileAlvaro Molina-Cruz²,
View ORCID ProfileLindsey M. Orchard³,
Clare K. Cimperman¹,
Chen-Feng Qi¹,
Philipp Ross³,§,
View ORCID ProfileTakele Yazew¹,
Daniel Sturdevant⁴,
Sarah L. Anzick⁴,
View ORCID ProfileGirija Thiruvengadam²,||,
View ORCID ProfileThomas Dan Otto⁵,
View ORCID ProfileOliver Billker⁶,⁷,
View ORCID ProfileManuel Llinás³,⁸,
Louis H. Miller² and
View ORCID ProfileSusan K. Pierce ¹,*

¹Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
²Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
³Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, USA.
⁴Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
⁵Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
⁶Department of Molecular Biology, Umeå University, S-90187 Umeå, Sweden.
⁷Laboratory for Molecular Infection Medicine Sweden, Umeå University, S-90187 Umeå, Sweden.
⁸Department of Chemistry, Pennsylvania State University, University Park, PA, USA.

↵*Corresponding author. Email: spierce{at}nih.gov (S.K.P.); munir.akkaya{at}nih.gov (M.A.)

↵† Present address: School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
↵‡ Present address: Department of Neurology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
↵§ Present address: Genetics, Genomics and Systems Biology Program, University of Chicago, Chicago, IL, USA.
↵|| Present address: Center for Genetic Medicine Research, Children’s National Medical Center, Washington, DC, USA.

See allHide authors and affiliations

Science Advances 05 Feb 2020:
Vol. 6, no. 6, eaaw6957
DOI: 10.1126/sciadv.aaw6957

Munir Akkaya

1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Munir Akkaya
For correspondence: spierce@nih.gov munir.akkaya@nih.gov

Abhisheka Bansal

2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Patrick W. Sheehan

1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Patrick W. Sheehan

Mirna Pena

1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alvaro Molina-Cruz

2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alvaro Molina-Cruz

Lindsey M. Orchard

3Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Lindsey M. Orchard

Clare K. Cimperman

1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Chen-Feng Qi

1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Philipp Ross

3Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Takele Yazew

1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Takele Yazew

Daniel Sturdevant

4Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sarah L. Anzick

4Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Girija Thiruvengadam

2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Girija Thiruvengadam

Thomas Dan Otto

5Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Thomas Dan Otto

Oliver Billker

6Department of Molecular Biology, Umeå University, S-90187 Umeå, Sweden.

7Laboratory for Molecular Infection Medicine Sweden, Umeå University, S-90187 Umeå, Sweden.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Oliver Billker

Manuel Llinás

3Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, USA.

8Department of Chemistry, Pennsylvania State University, University Park, PA, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Manuel Llinás

Louis H. Miller

2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Susan K. Pierce

1Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Susan K. Pierce
For correspondence: spierce@nih.gov munir.akkaya@nih.gov

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all . Please read our guidelines before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity

Plain text

Vertical Tabs

Science Advances

Article Tools