Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids

Batuujin Burendei; Ruriko Shinozaki; Masakatsu Watanabe; Tohru Terada; Kazutoshi Tani; Yoshinori Fujiyoshi; Atsunori Oshima

doi:10.1126/sciadv.aax3157

Research ArticleSTRUCTURAL BIOLOGY

Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids

View ORCID ProfileBatuujin Burendei¹,
Ruriko Shinozaki²,
View ORCID ProfileMasakatsu Watanabe ³,
View ORCID ProfileTohru Terada ⁴,
View ORCID ProfileKazutoshi Tani ⁵,*,
View ORCID ProfileYoshinori Fujiyoshi ⁵,⁶,† and
View ORCID ProfileAtsunori Oshima ²,⁵,‡

¹Division of Biological Science, School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
²Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
³Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.
⁴Interfaculty Initiative in Information Studies, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
⁵Cellular and Structural Physiology Institute (CeSPI), Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
⁶CeSPIA Inc., Ōtemachi, Chiyoda, Tokyo 100-0004, Japan.

↵‡Corresponding author. Email: atsu{at}cespi.nagoya-u.ac.jp

↵* Present address: Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
↵† Present address: Advanced Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

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Science Advances 12 Feb 2020:
Vol. 6, no. 7, eaax3157
DOI: 10.1126/sciadv.aax3157

Batuujin Burendei

1Division of Biological Science, School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

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ORCID record for Batuujin Burendei

Ruriko Shinozaki

2Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

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Masakatsu Watanabe

3Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.

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Tohru Terada

4Interfaculty Initiative in Information Studies, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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Kazutoshi Tani

5Cellular and Structural Physiology Institute (CeSPI), Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

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Yoshinori Fujiyoshi

5Cellular and Structural Physiology Institute (CeSPI), Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

6CeSPIA Inc., Ōtemachi, Chiyoda, Tokyo 100-0004, Japan.

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Atsunori Oshima

2Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

5Cellular and Structural Physiology Institute (CeSPI), Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.

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For correspondence: atsu@cespi.nagoya-u.ac.jp

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Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids

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