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Research ArticleMOLECULAR BIOLOGY
Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions
- View ORCID ProfileM. A. Gonzalez-Lozano1,
- View ORCID ProfileF. Koopmans1,
- View ORCID ProfileP. F. Sullivan2,3,
- View ORCID ProfileJ. Protze4,
- G. Krause4,
- M. Verhage5,
- View ORCID ProfileK. W. Li1,*,
- View ORCID ProfileF. Liu6,7,*,† and
- View ORCID ProfileA. B. Smit1,*,†
- 1Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
- 2Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
- 3Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
- 4Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
- 5Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
- 6Department of Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
- 7Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
- ↵*Corresponding author. Email: k.w.li{at}vu.nl (K.W.L.); fliu{at}fmp-berlin.de (F.L.); guus.smit{at}vu.nl (A.B.S.)
↵† These authors contributed equally to this work.
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Science Advances 19 Feb 2020:
Vol. 6, no. 8, eaax5783
DOI: 10.1126/sciadv.aax5783
Vol. 6, no. 8, eaax5783
DOI: 10.1126/sciadv.aax5783
M. A. Gonzalez-Lozano
1Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
F. Koopmans
1Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
P. F. Sullivan
2Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
3Departments of Genetics and Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
J. Protze
4Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
G. Krause
4Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
M. Verhage
5Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
K. W. Li
1Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
F. Liu
6Department of Chemical Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
7Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands.
A. B. Smit
1Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
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