Research ArticleHEALTH AND MEDICINE

Vascular endothelium–targeted Sirt7 gene therapy rejuvenates blood vessels and extends life span in a Hutchinson-Gilford progeria model

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Science Advances  19 Feb 2020:
Vol. 6, no. 8, eaay5556
DOI: 10.1126/sciadv.aay5556

Article Information

vol. 6 no. 8

Online ISSN: 
History: 
  • Received for publication June 28, 2019
  • Accepted for publication December 4, 2019
  • .

Author Information

  1. Shimin Sun1,2,3,*,
  2. Weifeng Qin2,3,*,
  3. Xiaolong Tang2,3,*,
  4. Yuan Meng2,3,
  5. Wenjing Hu2,
  6. Shuju Zhang2,3,
  7. Minxian Qian2,3,4,
  8. Zuojun Liu2,3,4,
  9. Xinyue Cao2,3,4,
  10. Qiuxiang Pang1,
  11. Bosheng Zhao1,
  12. Zimei Wang3,4,
  13. Zhongjun Zhou5 and
  14. Baohua Liu2,3,4,6,
  1. 1Anti-aging & Regenerative Medicine Research Institution, School of Life Sciences, Shandong University of Technology, Zibo 255049, China.
  2. 2National Engineering Research Center for Biotechnology (Shenzhen), Carson International Cancer Center, Medical Research Center, Shenzhen University Health Science Center, Shenzhen, China.
  3. 3Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen, China.
  4. 4Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen 518055, China.
  5. 5School of Biological Sciences, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
  6. 6Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen 518055, China.
  1. Corresponding author. Email: ppliew{at}szu.edu.cn
  • * These authors contributed equally to this work.

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