Research ArticleSYNTHETIC BIOLOGY

Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice

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Science Advances  01 Jan 2021:
Vol. 7, no. 1, eabd3568
DOI: 10.1126/sciadv.abd3568

Article Information

vol. 7 no. 1

PubMed: 
Online ISSN: 
History: 
  • Received for publication June 17, 2020
  • Accepted for publication November 6, 2020
  • .

Author Information

  1. Nils Schneider1,2,*,,
  2. Franz-Georg Wieland1,3,4,,
  3. Deqiang Kong5,
  4. Alexandra A. M. Fischer1,2,6,
  5. Maximilian Hörner1,2,
  6. Jens Timmer1,3,
  7. Haifeng Ye5 and
  8. Wilfried Weber1,2,6,
  1. 1Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany.
  2. 2Faculty of Biology, University of Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany.
  3. 3Institute of Physics, University of Freiburg, Hermann-Herder-Straße 3, 79104 Freiburg, Germany.
  4. 4Freiburg Center for Data Analysis and Modelling (FDM), University of Freiburg, Ernst-Zermelo-Str. 1, 79104 Freiburg, Germany.
  5. 5Synthetic Biology and Biomedical Engineering Laboratory, Biomedical Synthetic Biology Research Center, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Dongchuan Road 500, Shanghai 200241, China.
  6. 6Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Albertstrasse 21a, 79104 Freiburg, Germany.
  1. Corresponding author. Email: wilfried.weber{at}biologie.uni-freiburg.de
  • * Present address: Celonic AG, Eulerstraße 55, 4051 Basel, Switzerland.

  • These authors contributed equally to this work.

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Article usage: December 2020 to April 2021

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Mar 202181599266
Apr 202174343125

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