Research ArticleHEALTH AND MEDICINE

BBB pathophysiology–independent delivery of siRNA in traumatic brain injury

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Science Advances  01 Jan 2021:
Vol. 7, no. 1, eabd6889
DOI: 10.1126/sciadv.abd6889

Article Information

vol. 7 no. 1

PubMed: 
Online ISSN: 
History: 
  • Received for publication July 6, 2020
  • Accepted for publication November 3, 2020
  • .

Author Information

  1. Wen Li1,2,3,
  2. Jianhua Qiu3,4,
  3. Xiang-Ling Li1,
  4. Sezin Aday1,2,
  5. Jingdong Zhang4,5,
  6. Grace Conley4,
  7. Jun Xu1,3,
  8. John Joseph1,3,
  9. Haoyue Lan1,
  10. Robert Langer2,6,
  11. Rebekah Mannix3,4,*,
  12. Jeffrey M. Karp1,3,6,7,8,* and
  13. Nitin Joshi1,2,3,*
  1. 1Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  2. 2Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  3. 3Harvard Medical School, Boston, MA 02115, USA.
  4. 4Division of Emergency Medicine, Boston Children’s Hospital, Boston, MA 02115, USA.
  5. 5Department of Neurosurgery, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  6. 6Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  7. 7Broad Institute, Cambridge, MA 02142, USA.
  8. 8Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
  1. *Corresponding author. Email: rebekah.mannix{at}childrens.harvard.edu (R.M.); jmkarp{at}bwh.harvard.edu (J.M.K.); njoshi{at}bwh.harvard.edu (N.J.)

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