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JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality

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Science Advances  01 Jan 2021:
Vol. 7, no. 1, eabe4724
DOI: 10.1126/sciadv.abe4724

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vol. 7 no. 1

PubMed: 
Online ISSN: 
History: 
  • Received for publication August 24, 2020
  • Accepted for publication October 28, 2020
  • .

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Author Information

  1. Justin Stebbing1,*,,
  2. Ginés Sánchez Nievas2,,
  3. Marco Falcone3,,
  4. Sonia Youhanna4,,
  5. Peter Richardson5,
  6. Silvia Ottaviani1,
  7. Joanne X. Shen4,
  8. Christian Sommerauer6,
  9. Giusy Tiseo3,
  10. Lorenzo Ghiadoni3,
  11. Agostino Virdis3,
  12. Fabio Monzani3,
  13. Luis Romero Rizos7,8,
  14. Francesco Forfori9,
  15. Almudena Avendaño Céspedes7,8,
  16. Salvatore De Marco10,
  17. Laura Carrozzi9,
  18. Fabio Lena11,
  19. Pedro Manuel Sánchez-Jurado7,8,
  20. Leonardo Gianluca Lacerenza11,
  21. Nencioni Cesira12,
  22. David Caldevilla Bernardo13,
  23. Antonio Perrella12,
  24. Laura Niccoli14,
  25. Lourdes Sáez Méndez15,
  26. Daniela Matarrese16,
  27. Delia Goletti17,
  28. Yee-Joo Tan18,
  29. Vanessa Monteil19,
  30. George Dranitsaris20,
  31. Fabrizio Cantini14,
  32. Alessio Farcomeni21,
  33. Shuchismita Dutta22,
  34. Stephen K. Burley22,
  35. Haibo Zhang23,
  36. Mauro Pistello24,
  37. William Li25,
  38. Marta Mas Romero7,
  39. Fernando Andrés Pretel26,
  40. Rafaela Sánchez Simón-Talero27,
  41. Rafael García-Molina7,
  42. Claudia Kutter6,
  43. James H. Felce28,
  44. Zehra F. Nizami28,
  45. Andras G. Miklosi28,
  46. Josef M. Penninger29,30,
  47. Francesco Menichetti3,,
  48. Ali Mirazimi18,,
  49. Pedro Abizanda7,8, and
  50. Volker M. Lauschke4,*,
  1. 1Department of Surgery and Cancer, Imperial College, London, UK.
  2. 2Department of Rheumatology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  3. 3Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  4. 4Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
  5. 5BenevolentAI, Maple Street, London, UK.
  6. 6Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Science for Life Laboratory, Solna, Sweden.
  7. 7Department of Geriatric Medicine, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  8. 8CIBERFES, Ministerio de Economía y Competitividad, Madrid, Spain.
  9. 9Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Pisa, University of Pisa, Italy.
  10. 10Department of Internal Medicine, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
  11. 11Department of Pharmaceutical Medicine, Misericordia Hospital, Grosseto, Italy.
  12. 12Department of Medicine, Misericordia Hospital, Grosseto, Italy.
  13. 13Department of Radiology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  14. 14Department of Rheumatology, Hospital of Prato, Prato, Italy.
  15. 15Department of Internal Medicine, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  16. 16Hospital Network ASL Toscana Centro, Toscana, Italy.
  17. 17Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases–IRCCS, Rome, Italy.
  18. 18University of Singapore, Infectious Diseases Programme, Immunology Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore and Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.
  19. 19Karolinska Institutet, Department of Laboratory Medicine, Unit of Clinical Microbiology, and SE-17177, Stockholm, Sweden.
  20. 20Department of Hematology, School of Medicine, University of Ioannina, Ioannina, Greece.
  21. 21Department of Economics and Finance, University of Rome Tor Vergata, Rome Italy.
  22. 22RCSB Protein Data Bank, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
  23. 23Departments of Anesthesia, Medicine, and Physiology, University of Toronto, Toronto, ON, Canada.
  24. 24Virology Unit, Department of Translational Research, University of Pisa, Pisa, Italy.
  25. 25The Angiogenesis Foundation, Cambridge, MA, USA.
  26. 26Department of Statistics, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  27. 27Department of Pneumology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  28. 28Oxford Nanoimaging, Oxford, UK.
  29. 29Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
  30. 30Department of Medical Genetics, Life Science Institute, University of British Columbia, Vancouver, BC, Canada.
  31. 31National Veterinary Institute, Uppsala, Sweden.
  1. *Corresponding author. Email: j.stebbing{at}imperial.ac.uk (J.S.); volker.lauschke{at}ki.se (V.M.L.)
  • These authors contributed equally to this work.

  • These authors contributed equally to this work.

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