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Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

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Science Advances  01 Jan 2021:
Vol. 7, no. 1, eabe5575
DOI: 10.1126/sciadv.abe5575

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vol. 7 no. 1

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Online ISSN: 
History: 
  • Received for publication August 29, 2020
  • Accepted for publication November 4, 2020
  • .

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Author Information

  1. Cong Xu1,2,*,
  2. Yanxing Wang1,*,
  3. Caixuan Liu1,2,*,
  4. Chao Zhang3,*,
  5. Wenyu Han1,2,*,
  6. Xiaoyu Hong1,2,
  7. Yifan Wang1,2,
  8. Qin Hong1,2,
  9. Shutian Wang1,2,
  10. Qiaoyu Zhao1,2,
  11. Yalei Wang3,
  12. Yong Yang3,
  13. Kaijian Chen1,2,
  14. Wei Zheng1,2,
  15. Liangliang Kong4,
  16. Fangfang Wang4,
  17. Qinyu Zuo1,
  18. Zhong Huang3, and
  19. Yao Cong1,5,
  1. 1State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
  2. 2University of Chinese Academy of Sciences, Beijing 100049, China.
  3. 3CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
  4. 4The National Facility for Protein Science in Shanghai (NFPS), Shanghai 201210, China.
  5. 5Shanghai Science Research Center, Chinese Academy of Sciences, Shanghai 201210, China.
  1. Corresponding author. Email: cong{at}sibcb.ac.cn (Y.C.); huangzhong{at}ips.ac.cn (Z.H.)
  • * These authors contributed equally to this work.

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