Contents
March 2021
Vol 7, Issue 12
Vol 7, Issue 12
Contents
Research Articles
- Massive clonal expansion of polycytotoxic skin and blood CD8+ T cells in patients with toxic epidermal necrolysis
This study highlights the key role of polycytotoxic CD8+ T cells in the severity of toxic epidermal necrolysis.
- Resilient three-dimensional ordered architectures assembled from nanoparticles by DNA
Resilient silica-nanoparticle lattices organized by DNA withstand harsh temperature, pressure and radiation conditions.
- Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison
Systematic comparison between two serial crystallography methods shows that both enable time-resolved measurements.
- Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates
SARS-CoV-2 receptor binding domain and S2GΔHR2 spike elicited potent immune responses when displayed on protein nanoparticles.
- Persistent repression of tau in the brain using engineered zinc finger protein transcription factors
Zinc finger proteins targeted to MAPT safely repress tau mRNA in the adult mouse brain and protect against Aβ toxicity.
- Breast cancer–secreted factors perturb murine bone growth in regions prone to metastasis
A correlative materials analysis approach reveals perturbed bone growth in a mouse model of premetastatic breast cancer.
- On-chip torsion balances with femtonewton force resolution at room temperature enabled by carbon nanotube and graphene
On-chip torsion balance with a CNT suspension wire and a graphene/Al ultrathin mirror is capable of detecting femtonewton force.
- GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer
GREB1 is an inducible cytoplasmic glycosyltransferase.
- Reversible 3D-2D structural phase transition and giant electronic modulation in nonequilibrium alloy semiconductor, lead-tin-selenide
3D-2D structural phase transition is artificially induced to invoke giant electronic modulation in nonequilibrium (Pb1−xSnx)Se.
- Lack of support for Deuterostomia prompts reinterpretation of the first Bilateria
The deuterostome animal groups (Chordata and Xenambulacraria) may not be each other’s closest relatives.
- The evolution of pelvic limb muscle moment arms in bird-line archosaurs
Biomechanical modeling shows that archosaur leg muscle leverage evolved gradually, yet with a Jurassic pulse of specialization.
- Multicolor three-photon fluorescence imaging with single-wavelength excitation deep in mouse brain
A new three-photon excitation scheme enables multicolor three-photon imaging deep in mouse brain with single-wavelength excitation.
- A tumor microenvironment–induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy
The tumor microenvironment–activated Fe-Cu@PANI nanoprobe is used for photoacoustic imaging and photothermal therapy.
- Strongly correlated superconductivity in a copper-based metal-organic framework with a perfect kagome lattice
A metal-organic framework with a perfect kagome lattice exhibits strongly correlated unconventional superconductivity.
- Low ABA concentration promotes root growth and hydrotropism through relief of ABA INSENSITIVE 1-mediated inhibition of plasma membrane H+-ATPase 2
ABI1 interacts with the C terminus of AHA2 and dephosphorylates Thr947 to negatively regulate root growth and hydrotropism.
- Symptom clusters in COVID-19: A potential clinical prediction tool from the COVID Symptom Study app
Longitudinal clustering of symptoms can predict the need for respiratory support in severe COVID-19.
- Severe violations of independence in response inhibition tasks
The keystone assumption of independence in computational models for response inhibition is severely violated.
- Nanotransfection-based vasculogenic cell reprogramming drives functional recovery in a mouse model of ischemic stroke
Fibroblasts nonvirally programmed to convert into induced endothelial cells show therapeutic potential for ischemic stroke.
- Catalytic amplification by transition-state molecular switches for direct and sensitive detection of SARS-CoV-2
Transition-state molecular switches enable hyper responsive detection of SARS-CoV-2 in native clinical samples.
- Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation
A paradoxical role for vascular COX-1 products in vasoconstriction and atherogenesis highlights it as a novel therapeutic target.
- Quantum key distribution with entangled photons generated on demand by a quantum dot
Quantum key distribution is demonstrated over an urban open-air link using entangled light from a semiconductor nanostructure.
- Deep learning velocity signals allow quantifying turbulence intensity
Deep learning velocity signals allow quantifying turbulence intensity from very short signals and with extremely high accuracy.
- Temporal mechanisms of myogenic specification in human induced pluripotent stem cells
Mechanisms of myogenic commitment are deciphered through omics analysis of hiPSC-specific lineage specification measurements.
- Nuclear genome-wide associations with mitochondrial heteroplasmy
This study identifies regions of the nuclear genome that affect heteroplasmy, the mixture of different mitochondrial DNA.
- Mutual anticipation can contribute to self-organization in human crowds
Mutual anticipation between pedestrians facilitates efficient transition to ordered flow of movement in human crowds.
- Actions on sustainable food production and consumption for the post-2020 global biodiversity framework
Actions to transform food systems are key to addressing biodiversity loss.
- Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target
Upregulation of N-type Ca2+ channel dependent subunits increases functional connections and synchronization for pain formation.
- All-optical reversible single-photon isolation at room temperature
Magnetic-free optical nonreciprocity has been experimentally demonstrated for a genuine single photon at room temperature.
- Bioinspired mechano-photonic artificial synapse based on graphene/MoS2 heterostructure
A bioinspired mechano-photonic artificial synapse with synergistic mechanical and optical plasticity is demonstrated.
- Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity
Structural analysis reveals how critical foldamer backbone plasticity is for optimal interaction with the target protein surface.
- Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids
3D multifunctional frameworks, as flexible as a single strand of silk, modulate and measure neural activity of brain spheroids.
- A towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffe
A chromosome-level giraffe genome assembly and gene-edited mice reveal molecular mechanisms underpinning its high stature.
- A clarified typology of core-periphery structure in networks
We introduce a new typology and corresponding statistical models for characterizing the core-periphery structure of networks.
- Lightscapes of fear: How mesopredators balance starvation and predation in the open ocean
Lightscapes affect life and death of elephant seals during oceanic migrations.
- IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis
Hippocampal microglia mediate stress resilience.
Review
- Immunogenicity of clinically relevant SARS-CoV-2 vaccines in nonhuman primates and humans
Clinically relevant SARS-CoV-2 vaccines induce protective responses in nonhuman primates and humans.
About The Cover
ONLINE COVER Engineered brain organoids reproduce complex features of the human brain in a laboratory setting, providing novel insights that could improve treatments for neurodevelopmental conditions, such as those caused by Zika virus, and neurodegenerative disorders, such as Parkinson's and Alzheimer's disease. However, conventional approaches to neuromodulation, sensing, and manipulation make it difficult to study these 3D living objects, undermining their potential applications. To address this challenge, Park et al. developed compliant, multifunctional 3D electronic interfaces that gently envelop organoids, enabling scientists to monitor and control their neural activity over long periods of time. The researchers performed systematic studies with cortical spheroids and assembloids formed from healthy human induced pluripotent stem cell (hiPSCs), finding that the interfaces successfully enabled scientists to investigate the organization and function of these systems' underlying neural networks. These novel interfaces may provide important tools to advance neuroscience research and regenerative medicine. [CREDIT: YOONSEOK PARK, NORTHWESTERN UNIVERSITY]
