March 2021
Vol 7, Issue 12

About The Cover

Cover image expansion

ONLINE COVER Engineered brain organoids reproduce complex features of the human brain in a laboratory setting, providing novel insights that could improve treatments for neurodevelopmental conditions, such as those caused by Zika virus, and neurodegenerative disorders, such as Parkinson's and Alzheimer's disease. However, conventional approaches to neuromodulation, sensing, and manipulation make it difficult to study these 3D living objects, undermining their potential applications. To address this challenge, Park et al. developed compliant, multifunctional 3D electronic interfaces that gently envelop organoids, enabling scientists to monitor and control their neural activity over long periods of time. The researchers performed systematic studies with cortical spheroids and assembloids formed from healthy human induced pluripotent stem cell (hiPSCs), finding that the interfaces successfully enabled scientists to investigate the organization and function of these systems' underlying neural networks. These novel interfaces may provide important tools to advance neuroscience research and regenerative medicine. [CREDIT: YOONSEOK PARK, NORTHWESTERN UNIVERSITY]