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Persistent repression of tau in the brain using engineered zinc finger protein transcription factors

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Science Advances  19 Mar 2021:
Vol. 7, no. 12, eabe1611
DOI: 10.1126/sciadv.abe1611

Article Information

vol. 7 no. 12

PubMed: 
Online ISSN: 
History: 
  • Received for publication August 10, 2020
  • Accepted for publication February 5, 2021
  • .

Author Information

  1. Susanne Wegmann1,2,*,,
  2. Sarah L. DeVos1,*,
  3. Bryan Zeitler3,*,,
  4. Kimberly Marlen3,
  5. Rachel E. Bennett1,
  6. Marta Perez-Rando1,
  7. Danny MacKenzie1,
  8. Qi Yu3,
  9. Caitlin Commins1,
  10. Riley N. Bannon1,,
  11. Bianca T. Corjuc1,
  12. Alison Chase1,
  13. Lisa Diez2,
  14. Hoang-Oanh B. Nguyen3,
  15. Sarah Hinkley3,
  16. Lei Zhang3,
  17. Alicia Goodwin3,
  18. Annemarie Ledeboer3,
  19. Stephen Lam3,
  20. Irina Ankoudinova3,
  21. Hung Tran3,
  22. Nicholas Scarlott3,
  23. Rainier Amora3,
  24. Richard Surosky3,
  25. Jeffrey C. Miller3,
  26. Ashley B. Robbins1,
  27. Edward J. Rebar3,§,
  28. Fyodor D. Urnov3,
  29. Michael C. Holmes3,
  30. Amy M. Pooler3,
  31. Brigit Riley3,
  32. H. Steve Zhang3,|| and
  33. Bradley T. Hyman1,
  1. 1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
  2. 2German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.
  3. 3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
  1. Corresponding author. Email: bzeitler{at}sangamo.com (B.Z.); susanne.wegmann{at}dzne.de (S.W.); bhyman{at}mgh.harvard.edu (B.T.H.)
  • * These authors contributed equally to this work.

  • Present address: Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.

  • § Present address: Sana Biotechnology, Inc., 1 Tower Pl., Suite 500, South San Francisco, CA 94080, USA.

  • || Present address: ASC Therapeutics Inc., Milpitas, CA 95035, USA.

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