Research ArticleNEUROSCIENCE
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors
- View ORCID ProfileSusanne Wegmann1,2,*,†,
- View ORCID ProfileSarah L. DeVos1,*,
- View ORCID ProfileBryan Zeitler3,*,†,
- View ORCID ProfileKimberly Marlen3,
- View ORCID ProfileRachel E. Bennett1,
- View ORCID ProfileMarta Perez-Rando1,
- View ORCID ProfileDanny MacKenzie1,
- Qi Yu3,
- Caitlin Commins1,
- Riley N. Bannon1,‡,
- View ORCID ProfileBianca T. Corjuc1,
- View ORCID ProfileAlison Chase1,
- View ORCID ProfileLisa Diez2,
- Hoang-Oanh B. Nguyen3,
- View ORCID ProfileSarah Hinkley3,
- View ORCID ProfileLei Zhang3,
- Alicia Goodwin3,
- Annemarie Ledeboer3,
- View ORCID ProfileStephen Lam3,
- Irina Ankoudinova3,
- Hung Tran3,
- View ORCID ProfileNicholas Scarlott3,
- View ORCID ProfileRainier Amora3,
- View ORCID ProfileRichard Surosky3,
- Jeffrey C. Miller3,
- View ORCID ProfileAshley B. Robbins1,
- Edward J. Rebar3,§,
- View ORCID ProfileFyodor D. Urnov3,
- View ORCID ProfileMichael C. Holmes3,
- Amy M. Pooler3,
- Brigit Riley3,
- H. Steve Zhang3,|| and
- View ORCID ProfileBradley T. Hyman1,†
- 1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
- 2German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.
- 3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
- ↵†Corresponding author. Email: bzeitler{at}sangamo.com (B.Z.); susanne.wegmann{at}dzne.de (S.W.); bhyman{at}mgh.harvard.edu (B.T.H.)
↵* These authors contributed equally to this work.
↵‡ Present address: Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
↵§ Present address: Sana Biotechnology, Inc., 1 Tower Pl., Suite 500, South San Francisco, CA 94080, USA.
↵|| Present address: ASC Therapeutics Inc., Milpitas, CA 95035, USA.
See allHide authors and affiliations
Science Advances 19 Mar 2021:
Vol. 7, no. 12, eabe1611
DOI: 10.1126/sciadv.abe1611
Vol. 7, no. 12, eabe1611
DOI: 10.1126/sciadv.abe1611
Susanne Wegmann
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
2German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.
Sarah L. DeVos
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
Bryan Zeitler
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Kimberly Marlen
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Rachel E. Bennett
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
Marta Perez-Rando
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
Danny MacKenzie
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
Qi Yu
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Caitlin Commins
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
Riley N. Bannon
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
Bianca T. Corjuc
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
Alison Chase
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
Lisa Diez
2German Center for Neurodegenerative Diseases (DZNE), 10117 Berlin, Germany.
Hoang-Oanh B. Nguyen
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Sarah Hinkley
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Lei Zhang
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Alicia Goodwin
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Annemarie Ledeboer
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Stephen Lam
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Irina Ankoudinova
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Hung Tran
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Nicholas Scarlott
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Rainier Amora
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Richard Surosky
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Jeffrey C. Miller
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Ashley B. Robbins
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
Edward J. Rebar
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Fyodor D. Urnov
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Michael C. Holmes
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Amy M. Pooler
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Brigit Riley
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
H. Steve Zhang
3Sangamo Therapeutics Inc., Richmond, CA 94804, USA.
Bradley T. Hyman
1Massachusetts General Hospital, Massachusetts Institute of Neurodegenerative Disease, Charlestown, MA 02129, USA.
