Research ArticleNEUROPHYSIOLOGY

Odontoblast TRPC5 channels signal cold pain in teeth

See allHide authors and affiliations

Science Advances  26 Mar 2021:
Vol. 7, no. 13, eabf5567
DOI: 10.1126/sciadv.abf5567

Article Information

vol. 7 no. 13

PubMed: 
Online ISSN: 
History: 
  • Received for publication November 3, 2020
  • Accepted for publication February 9, 2021
  • .

Author Information

  1. Laura Bernal1,2,*,
  2. Pamela Sotelo-Hitschfeld1,3,*,
  3. Christine König1,
  4. Viktor Sinica1,4,
  5. Amanda Wyatt5,
  6. Zoltan Winter1,,
  7. Alexander Hein6,,
  8. Filip Touska1,4,
  9. Susanne Reinhardt7,
  10. Aaron Tragl1,
  11. Ricardo Kusuda1,§,
  12. Philipp Wartenberg5,
  13. Allen Sclaroff8,
  14. John D. Pfeifer9,
  15. Fabien Ectors10,
  16. Andreas Dahl7,
  17. Marc Freichel11,
  18. Viktorie Vlachova4,
  19. Sebastian Brauchi3,12,
  20. Carolina Roza2,
  21. Ulrich Boehm5,
  22. David E. Clapham6,||,,
  23. Jochen K. Lennerz13, and
  24. Katharina Zimmermann1,
  1. 1Department of Anesthesiology, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg (FAU), Erlangen, Germany.
  2. 2Departamento de Biología de Sistemas, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
  3. 3Institute of Physiology, Faculty of Medicine and Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile.
  4. 4Department of Cellular Neurophysiology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
  5. 5Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.
  6. 6HHMI, Cardiovascular Division, Boston Children’s Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
  7. 7Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.
  8. 8Department of Otolaryngology, Washington University School of Medicine, St Louis, MO, USA.
  9. 9Department of Pathology, Washington University School of Medicine, St Louis, MO, USA.
  10. 10FARAH Mammalian Transgenics Platform, Liège University, Liège, Belgium.
  11. 11Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany.
  12. 12Millennium Nucleus of Ion Channel-associated Diseases (MiNICAD), Santiago, Chile.
  13. 13Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
  1. Corresponding author. Email: claphamd{at}hhmi.org (D.E.C.); jlennerz{at}partners.org (J.K.L.); katharina.zimmermann{at}fau.de (K.Z.)
  • * These authors contributed equally to this work.

  • Present address: Optical Imaging Centre Erlangen, Universität Erlangen-Nürnberg, Erlangen, Germany.

  • Present address: Department of Gynecology and Obstetrics, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg (FAU), Erlangen, Germany.

  • § On leave from: Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.

  • || Present address: Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.

Altmetric

Article usage

Article usage: March 2021 to May 2021

AbstractFullPdf
Mar 2021413126592062
Apr 20215388901488
May 20210731125

Stay Connected to Science Advances

Navigate This Article