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Reduced MC4R signaling alters nociceptive thresholds associated with red hair

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Science Advances  02 Apr 2021:
Vol. 7, no. 14, eabd1310
DOI: 10.1126/sciadv.abd1310

Article Information

vol. 7 no. 14

Online ISSN: 
  • Received for publication June 2, 2020
  • Accepted for publication February 16, 2021
  • .

Author Information

  1. Kathleen C. Robinson1,*,
  2. Lajos V. Kemény1,*,
  3. Gillian L. Fell1,,
  4. Andrea L. Hermann1,2,
  5. Jennifer Allouche1,
  6. Weihua Ding3,
  7. Ajay Yekkirala4,
  8. Jennifer J. Hsiao1,
  9. Mack Y. Su1,
  10. Nicholas Theodosakis1,
  11. Gabor Kozak5,6,
  12. Yuichi Takeuchi5,7,8,9,
  13. Shiqian Shen3,
  14. Antal Berenyi5,8,10,11,
  15. Jianren Mao3,
  16. Clifford J. Woolf4 and
  17. David E. Fisher1,
  1. 1Cutaneous Biology Research Center, Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
  2. 2Doctoral School of Clinical Medicine, University of Szeged, Szeged 6720, Hungary.
  3. 3MGH Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.
  4. 4FM Kirby Neurobiology Center, Boston Children’s Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
  5. 5MTA-SZTE ‘Momentum’ Oscillatory Neuronal Networks Research Group, Department of Physiology, Interdisciplinary Excellence Centre, University of Szeged, Szeged H-6720, Hungary.
  6. 6University Neurology Hospital and Hertie Institute for Clinical Brain Research, Tübingen, Germany
  7. 7Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
  8. 8Neurocybernetics Excellence Center, University of Szeged, 10 Dom sqr, Szeged 6720, Hungary.
  9. 9Department of Physiology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
  10. 10Neuroscience Institute, New York University, New York City, NY 10016, USA.
  11. 11HCEMM-USZ Magnetotherapeutics Research Group, University of Szeged, 10 Dom sqr, Szeged 6720, Hungary.
  1. Corresponding author. Email: dfisher3{at}
  • * These authors contributed equally to this work.

  • Present address: Department of Surgery, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA.


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