Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration

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Science Advances  02 Apr 2021:
Vol. 7, no. 14, eabf6654
DOI: 10.1126/sciadv.abf6654

Article Information

vol. 7 no. 14

Online ISSN: 
  • Received for publication November 11, 2020
  • Accepted for publication February 17, 2021
  • .

Author Information

  1. Yizhou Zhu1,2,3,,
  2. Hang Liang4,,
  3. Xiangmei Liu2,*,
  4. Jun Wu3,
  5. Cao Yang4,*,
  6. Tak Man Wong1,3,
  7. Kenny Y. H. Kwan1,3,
  8. Kenneth M. C. Cheung1,3,
  9. Shuilin Wu5 and
  10. Kelvin W. K. Yeung1,3,6,*
  1. 1Department of Orthopaedics & Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong 999077, China.
  2. 2School of Materials Science & Engineering, Hubei University, Wuhan 430062, China.
  3. 3Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma, Department of Orthopaedics and Traumatology, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518053, China.
  4. 4Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  5. 5School of Materials Science and Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.
  6. 6China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, China.
  1. *Corresponding author. Email: liuxiangmei1978{at} (X.L.); caoyangunion{at} (C.Y.); wkkyeung{at} (K.W.K.Y.)
  • These authors contributed equally to this work.


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