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Research ArticleBIOCHEMISTRY
Structure of TFIIK for phosphorylation of CTD of RNA polymerase II
- View ORCID ProfileTrevor van Eeuwen1,2,
- View ORCID ProfileTao Li3,
- View ORCID ProfileHee Jong Kim1,2,4,
- View ORCID ProfileJose J. Gorbea Colón1,2,
- View ORCID ProfileMitchell I. Parker5,6,
- View ORCID ProfileRoland L. Dunbrack5,
- Benjamin A. Garcia1,4,
- View ORCID ProfileKuang-Lei Tsai3,* and
- View ORCID ProfileKenji Murakami1,*
- 1Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 2Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 3Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
- 4Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 5Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
- 6Molecular and Cell Biology and Genetics Program, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
- ↵*Corresponding author. Email: kenjim{at}pennmedicine.upenn.edu (K.M.); kuang-lei.tsai{at}uth.tmc.edu (K.L.T.)
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Science Advances 07 Apr 2021:
Vol. 7, no. 15, eabd4420
DOI: 10.1126/sciadv.abd4420
Vol. 7, no. 15, eabd4420
DOI: 10.1126/sciadv.abd4420
Trevor van Eeuwen
1Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Tao Li
3Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Hee Jong Kim
1Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
4Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jose J. Gorbea Colón
1Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Mitchell I. Parker
5Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
6Molecular and Cell Biology and Genetics Program, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Roland L. Dunbrack
5Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Benjamin A. Garcia
1Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
4Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kuang-Lei Tsai
3Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Kenji Murakami
1Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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