Research ArticleCANCER
Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer
- View ORCID ProfileSu H. Park1,
- Ka-wing Fong1,
- View ORCID ProfileJung Kim1,2,
- Fang Wang1,
- View ORCID ProfileXiaodong Lu1,
- Yongik Lee1,
- View ORCID ProfileLourdes T. Brea1,
- Kristine Wadosky3,
- Chunming Guo4,
- Sarki A. Abdulkadir5,6,7,
- John D. Crispino1,6,8,9,
- Deyu Fang6,10,
- Panagiotis Ntziachristos6,7,8,
- View ORCID ProfileXin Liu11,
- View ORCID ProfileXue Li4,
- Yong Wan6,12,
- View ORCID ProfileDavid W. Goodrich3,
- Jonathan C. Zhao1,6 and
- View ORCID ProfileJindan Yu1,6,7,8,*
- 1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
- 2Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
- 3Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
- 4Department of Urology and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA.
- 5Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
- 6Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
- 7Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
- 8Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
- 9Division of Experimental Hematology, Department of Hematology, St. Jude Children’s Hospital, Memphis, TN, USA.
- 10Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
- 11Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
- 12Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine Chicago, IL, USA.
- ↵*Corresponding author. Email: jindan-yu{at}northwestern.edu
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Science Advances 07 Apr 2021:
Vol. 7, no. 15, eabe2261
DOI: 10.1126/sciadv.abe2261
Vol. 7, no. 15, eabe2261
DOI: 10.1126/sciadv.abe2261
Su H. Park
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Ka-wing Fong
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jung Kim
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
2Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Fang Wang
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Xiaodong Lu
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Yongik Lee
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Lourdes T. Brea
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kristine Wadosky
3Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Chunming Guo
4Department of Urology and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA.
Sarki A. Abdulkadir
5Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
6Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
7Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
John D. Crispino
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
6Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
8Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
9Division of Experimental Hematology, Department of Hematology, St. Jude Children’s Hospital, Memphis, TN, USA.
Deyu Fang
6Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
10Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Panagiotis Ntziachristos
6Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
7Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
8Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Xin Liu
11Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xue Li
4Department of Urology and Department of Surgery, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA.
Yong Wan
6Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
12Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine Chicago, IL, USA.
David W. Goodrich
3Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Jonathan C. Zhao
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
6Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
Jindan Yu
1Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
6Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
7Simpson Querrey Center for Epigenetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
8Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
