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Research ArticleCELL BIOLOGY
AMPK/ULK1-mediated phosphorylation of Parkin ACT domain mediates an early step in mitophagy
- View ORCID ProfileChien-Min Hung1,†,
- View ORCID ProfilePortia S. Lombardo1,†,
- View ORCID ProfileNazma Malik1,
- Sonja N. Brun1,
- Kristina Hellberg1,
- View ORCID ProfileJeanine L. Van Nostrand1,
- View ORCID ProfileDaniel Garcia1,
- Joshua Baumgart1,
- Ken Diffenderfer2,
- View ORCID ProfileJohn M. Asara3 and
- View ORCID ProfileReuben J. Shaw1,*
- 1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
- 2Stem Cell Core Facility, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
- 3Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
- ↵*Corresponding author. Email: shaw{at}salk.edu
↵† These authors contributed equally to this work.
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Science Advances 07 Apr 2021:
Vol. 7, no. 15, eabg4544
DOI: 10.1126/sciadv.abg4544
Vol. 7, no. 15, eabg4544
DOI: 10.1126/sciadv.abg4544
Chien-Min Hung
1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Portia S. Lombardo
1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Nazma Malik
1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Sonja N. Brun
1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Kristina Hellberg
1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Jeanine L. Van Nostrand
1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Daniel Garcia
1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Joshua Baumgart
1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Ken Diffenderfer
2Stem Cell Core Facility, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
John M. Asara
3Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Reuben J. Shaw
1Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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