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Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion

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Science Advances  30 Apr 2021:
Vol. 7, no. 18, eabd2710
DOI: 10.1126/sciadv.abd2710

Article Information

vol. 7 no. 18

Online ISSN: 
  • Received for publication June 11, 2020
  • Accepted for publication March 10, 2021
  • .

Author Information

  1. Chen Zhu1,,
  2. Karen O. Dixon1,2,,
  3. Kathleen Newcomer3,4,
  4. Guangxiang Gu1,
  5. Sheng Xiao5,
  6. Sarah Zaghouani1,
  7. Markus A. Schramm1,
  8. Chao Wang1,,
  9. Huiyuan Zhang1,
  10. Kouichiro Goto6,
  11. Elena Christian4,
  12. Manu Rangachari7,8,
  13. Orit Rosenblatt-Rosen4,§,
  14. Hitoshi Okada9,
  15. Tak Mak6,
  16. Meromit Singer2,3,4,||,
  17. Aviv Regev10,11,§ and
  18. Vijay Kuchroo1,2,*
  1. 1Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA.
  2. 2Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  3. 3Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Department of Data Sciences, DFCI, Boston, MA 02215, USA.
  5. 5Celsius Therapeutics, Cambridge, MA 02139, USA.
  6. 6The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University of Health Network, Toronto, Ontario M5G 2M9, Canada.
  7. 7Axe Neurosciences, Centre de recherche du CHU de Québec-Université Laval, QC, Québec, Canada.
  8. 8Department of Molecular Medicine, Faculty of Medicine, Laval University, Québec, QC, Canada.
  9. 9Department of Biochemistry, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.
  10. 10Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biology, Koch Institute and Ludwig Center, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  11. 11Howard Hughes Medical Institute, Chevy Chase, MD, USA.
  1. *Corresponding author. Email: vkuchroo{at}
  • These authors contributed equally to this work.

  • Present address: Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada.

  • § Present address: Genentech, 1 DNA Way, South San Francisco, CA 94025, USA.

  • || Present address: Guardant Health, 505 Penobscot Dr, Redwood City, CA 94063, USA.


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