Research ArticleCANCER

Topography of transcriptionally active chromatin in glioblastoma

See allHide authors and affiliations

Science Advances  30 Apr 2021:
Vol. 7, no. 18, eabd4676
DOI: 10.1126/sciadv.abd4676

Article Information

vol. 7 no. 18

PubMed: 
Online ISSN: 
History: 
  • Received for publication July 7, 2020
  • Accepted for publication March 8, 2021
  • .

Author Information

  1. Liang Xu1,2,*,,,
  2. Ye Chen1,*,,
  3. Yulun Huang3,4,5,,
  4. Edwin Sandanaraj6,7,
  5. John S. Yu8,
  6. Ruby Yu-Tong Lin1,
  7. Pushkar Dakle1,
  8. Xin-Yu Ke1,
  9. Yuk Kien Chong6,
  10. Lynnette Koh6,9,
  11. Anand Mayakonda1,
  12. Kassoum Nacro10,
  13. Jeffrey Hill11,
  14. Mo-Li Huang1,12,
  15. Sigal Gery13,
  16. See Wee Lim6,
  17. Zhengyun Huang14,
  18. Ying Xu14,
  19. Jianxiang Chen15,16,17,
  20. Longchuan Bai18,19,
  21. Shaomeng Wang18,19,20,21,
  22. Hiroaki Wakimoto22,
  23. Tseng Tsai Yeo23,
  24. Beng Ti Ang24,25,
  25. Markus Müschen26,27,
  26. Carol Tang6,9,28,
  27. Tuan Zea Tan1,* and
  28. H. Phillip Koeffler1,13,23
  1. 1Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore.
  2. 2College of Life Sciences, Zhejiang University, Hangzhou, 310058, China.
  3. 3Department of Neurosurgery, Dushu Lake Hospital Affiliated of Soochow University, Suzhou, 215124, China.
  4. 4Department of Neurosurgery, Medical Center of Soochow University, Suzhou, 215124, China.
  5. 5Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
  6. 6Department of Research, National Neuroscience Institute, 308433, Singapore.
  7. 7Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, 117609, Singapore.
  8. 8Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  9. 9School of Biological Sciences, Nanyang Technological University, 637551, Singapore.
  10. 10Experimental Drug Development Centre, Agency for Science, Technology and Research, 138670, Singapore.
  11. 11Sussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK.
  12. 12School of Biology and Basic Medical Sciences, Soochow University, Suzhou, 215123, China.
  13. 13Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  14. 14Cambridge-Suda Genomic Research Center, Soochow University, Suzhou, 215123, China.
  15. 15College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China.
  16. 16Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China.
  17. 17Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.
  18. 18Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
  19. 19Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
  20. 20Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
  21. 21Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
  22. 22Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  23. 23National University Cancer Institute, National University Hospital, 119074, Singapore.
  24. 24Department of Neurosurgery, National Neuroscience Institute, 308433, Singapore.
  25. 25Duke-National University of Singapore Medical School, 169857, Singapore.
  26. 26Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06511, USA.
  27. 27Department of Immunobiology, Yale University, New Haven, CT 06511, USA.
  28. 28Cancer and Stem Cell Biology Program, Duke-National University of Singapore Medical School, 169857, Singapore.
  1. *Corresponding author. Email: xuliang.zju{at}gmail.com (L.X.); csicye{at}nus.edu.sg (Y.C.); csittz{at}nus.edu.sg (T.Z.T.)
  • These authors contributed equally to this work.

  • Lead contact.

Altmetric

Article usage

Article usage: April 2021 to June 2021

AbstractFullPdf
Apr 20211431061107
May 20211622181757
Jun 20212441893

Stay Connected to Science Advances

Navigate This Article