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Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation

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Science Advances  28 Apr 2021:
Vol. 7, no. 18, eabd4742
DOI: 10.1126/sciadv.abd4742

Article Information

vol. 7 no. 18

PubMed: 
Online ISSN: 
History: 
  • Received for publication June 23, 2020
  • Accepted for publication March 8, 2021
  • .

Author Information

  1. Jiyu Tong1,2,3,,
  2. Xuefei Wang1,2,,
  3. Yongbo Liu1,2,,
  4. Xingxing Ren4,,
  5. Anmin Wang4,
  6. Zonggui Chen5,
  7. Jiameng Yao1,
  8. Kaiqiong Mao1,2,
  9. Tingting Liu6,7,
  10. Fei-Long Meng6,7,
  11. Wen Pan4,
  12. Qiang Zou1,
  13. Jun Liu8,
  14. Yu Zhou5,
  15. Qiang Xia9,*,
  16. Richard A. Flavell10,11,*,
  17. Shu Zhu4,* and
  18. Hua-Bing Li1,2,9,*
  1. 1Shanghai Institute of Immunology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  2. 2Shanghai Jiao Tong University School of Medicine–Yale Institute for Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  3. 3Department of Pediatrics and Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, Sichuan University, China.
  4. 4Hefei National Laboratory for Physical Sciences at Microscale, the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, 230027 Hefei, China.
  5. 5Institute for Advanced Studies, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.
  6. 6State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
  7. 7University of Chinese Academy of Sciences, Beijing 100049, China.
  8. 8School of Life Sciences, Peking University, Beijing 100871, China.
  9. 9Department of Liver Surgery and State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.
  10. 10Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8055, USA.
  11. 11Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520-8055, USA.
  1. *Corresponding author. Email: xiaqiang{at}medmail.com.cn (Q.X.); zhushu{at}ustc.edu.cn (S.Z.); richard.flavell{at}yale.edu (R.A.F.); huabing.li{at}shsmu.edu.cn (H.-B.L.)
  • These authors contributed equally to this work.

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