TRIM26 is a critical host factor for HCV replication and contributes to host tropism

Yisha Liang; Guigen Zhang; Qiheng Li; Lin Han; Xiaoyou Hu; Yu Guo; Wanyin Tao; Xiaomin Zhao; Mingzhe Guo; Tianyu Gan; Yimin Tong; Yongfen Xu; Zhuo Zhou; Qiang Ding; Wensheng Wei; Jin Zhong

doi:10.1126/sciadv.abd9732

Research ArticleVIROLOGY

TRIM26 is a critical host factor for HCV replication and contributes to host tropism

View ORCID ProfileYisha Liang¹,²,³,*,
View ORCID ProfileGuigen Zhang⁴,⁵,*,†,
View ORCID ProfileQiheng Li⁴,*,
Lin Han¹,²,³,
Xiaoyou Hu¹,³,
View ORCID ProfileYu Guo⁴,
View ORCID ProfileWanyin Tao¹,‡,
Xiaomin Zhao⁶,
Mingzhe Guo¹,²,³,
Tianyu Gan¹,³,
Yimin Tong ¹,
Yongfen Xu¹,
Zhuo Zhou ⁴,
Qiang Ding⁶,
View ORCID ProfileWensheng Wei ⁴,† and
View ORCID ProfileJin Zhong ¹,²,³,†

¹Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
²School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
³University of Chinese Academy of Sciences, Beijing 100049, China.
⁴Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.
⁵Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510000, China.
⁶Center for Infectious Diseases Research, School of Medicine, Tsinghua University, Beijing 100084, China.

↵†Corresponding author. Email: jzhong{at}ips.ac.cn (J.Z.); wswei{at}pku.edu.cn (W.W.); zhanggg5{at}mail.sysu.edu.cn (G.Z.)

↵* Co-first authors.
↵‡ Present address: Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230000, China.

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Science Advances 08 Jan 2021:
Vol. 7, no. 2, eabd9732
DOI: 10.1126/sciadv.abd9732

Yisha Liang

1Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

2School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

3University of Chinese Academy of Sciences, Beijing 100049, China.

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Guigen Zhang

4Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing 100871, China.

5Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510000, China.

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For correspondence: jzhong@ips.ac.cn wswei@pku.edu.cn zhanggg5@mail.sysu.edu.cn

Qiheng Li

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Lin Han

1Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

2School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

3University of Chinese Academy of Sciences, Beijing 100049, China.

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Xiaoyou Hu

1Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

3University of Chinese Academy of Sciences, Beijing 100049, China.

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Yu Guo

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Wanyin Tao

1Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

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Xiaomin Zhao

6Center for Infectious Diseases Research, School of Medicine, Tsinghua University, Beijing 100084, China.

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Mingzhe Guo

1Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

2School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

3University of Chinese Academy of Sciences, Beijing 100049, China.

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Tianyu Gan

1Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

3University of Chinese Academy of Sciences, Beijing 100049, China.

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Yimin Tong

1Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

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Yongfen Xu

1Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

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Zhuo Zhou

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Qiang Ding

6Center for Infectious Diseases Research, School of Medicine, Tsinghua University, Beijing 100084, China.

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Wensheng Wei

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For correspondence: jzhong@ips.ac.cn wswei@pku.edu.cn zhanggg5@mail.sysu.edu.cn

Jin Zhong

1Unit of Viral Hepatitis, CAS Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

2School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

3University of Chinese Academy of Sciences, Beijing 100049, China.

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ORCID record for Jin Zhong
For correspondence: jzhong@ips.ac.cn wswei@pku.edu.cn zhanggg5@mail.sysu.edu.cn

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