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Stable but not rigid: Chronic in vivo STED nanoscopy reveals extensive remodeling of spines, indicating multiple drivers of plasticity

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Science Advances  09 Jun 2021:
Vol. 7, no. 24, eabf2806
DOI: 10.1126/sciadv.abf2806

Article Information

vol. 7 no. 24

Online ISSN: 
  • Received for publication October 15, 2020
  • Accepted for publication April 22, 2021
  • .

Author Information

  1. Heinz Steffens1,2,
  2. Alexander C. Mott1,2,
  3. Siyuan Li3,4,
  4. Waja Wegner1,2,
  5. Pavel Švehla3,4,
  6. Vanessa W. Y. Kan3,4,
  7. Fred Wolf2,5,
  8. Sabine Liebscher3,4,6,*, and
  9. Katrin I. Willig1,2,7,*,
  1. 1Optical Nanoscopy in Neuroscience, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, Göttingen, Germany.
  2. 2Max Planck Institute of Experimental Medicine, Göttingen, Germany.
  3. 3Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
  4. 4BioMedical Center, Faculty of Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.
  5. 5Max Planck Institute for Dynamics and Self-Organization; Campus Institute for Dynamics of Biological Networks, Göttingen, Germany.
  6. 6Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  7. 7Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen, Göttingen, Germany.
  1. *Corresponding author. Email: sabine.liebscher{at} (S.Lie.); kwillig{at} (K.I.W.)
  • These authors contributed equally to this work.


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