Research ArticleSTRUCTURAL BIOLOGY

Endogenous agonist–bound S1PR3 structure reveals determinants of G protein–subtype bias

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Science Advances  09 Jun 2021:
Vol. 7, no. 24, eabf5325
DOI: 10.1126/sciadv.abf5325

Article Information

vol. 7 no. 24

PubMed: 
Online ISSN: 
History: 
  • Received for publication November 2, 2020
  • Accepted for publication April 21, 2021
  • .

Author Information

  1. Shintaro Maeda1,2,
  2. Yuki Shiimura3,4,
  3. Hidetsugu Asada3,
  4. Kunio Hirata5,
  5. Fangjia Luo3,5,
  6. Eriko Nango3,5,6,
  7. Nobuo Tanaka7,
  8. Masayasu Toyomoto1,8,
  9. Asuka Inoue9,
  10. Junken Aoki9,,
  11. So Iwata3,5,* and
  12. Masatoshi Hagiwara1,2,7,8,*
  1. 1Department of Anatomy and Developmental Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
  2. 2Department of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.
  3. 3Department of Cell Biology, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
  4. 4Institute of Life Science, Kurume University, Kurume, Fukuoka 830-0011, Japan.
  5. 5RIKEN SPring-8 Center, Sayo-cho, Sayo-gun, Hyogo 679-5165, Japan.
  6. 6Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
  7. 7Medical Research Support Center, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
  8. 8Department of Drug Discovery for Lung Diseases, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
  9. 9Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan.
  1. *Corresponding author. Email: hagiwara.masatoshi.8c{at}kyoto-u.ac.jp (M.H.); (s.iwata{at}mfour.med.kyoto-u.ac.jp (S.I.)
  • Present address: Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Bunkyo-ku, Hongo, Tokyo 113-0033, Japan.

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