Contents
January 2021
Vol 7, Issue 3
Vol 7, Issue 3
Contents
Research Articles
- Spin-orbit coupling suppression and singlet-state blocking of spin-triplet Cooper pairs
Spin-polarized supercurrents interact with spin-orbit coupling and experience resistance in a superconductor.
- Ultrahigh-yield on-surface synthesis and assembly of circumcoronene into a chiral electronic Kagome-honeycomb lattice
Bottom-up surface-assisted synthesis of circumcoronene self-assembly enables realization of artificial electronic lattice.
- Single-cell cytometry via multiplexed fluorescence prediction by label-free reflectance microscopy
Deep learning–augmented reflectance microscopy enables label-free multiplexed cytometry.
- Strontium ions protect hearts against myocardial ischemia/reperfusion injury
A strontium-containing hydrogel protects hearts against myocardial ischemia/reperfusion injury.
- Systemic inequalities for LGBTQ professionals in STEM
LGBTQ STEM professionals experience more career limitations, devaluation, health issues, and attrition intentions than their peers.
- Ionizable lipid nanoparticles for in utero mRNA delivery
Lipid nanoparticles deliver mRNA to mouse fetuses, which may ultimately enable in utero therapy to treat fetal genetic diseases.
- How close are we to the temperature tipping point of the terrestrial biosphere?
Future anticipated warming could reduce the terrestrial carbon sink by ~50% by mid-century.
- CMOS-compatible ferroelectric NAND flash memory for high-density, low-power, and high-speed three-dimensional memory
A unique three-dimensional integration strategy is provided for high-performance, ultrahigh-density ferroelectric memory.
- Corner-, edge-, and facet-controlled growth of nanocrystals
Energy barrier profiles and reducing conditions yield control over corner-, edge-, and facet-specific nanoparticle growth.
- The Rab32/BLOC-3–dependent pathway mediates host defense against different pathogens in human macrophages
The small GTPase Rab32 and its exchange factor BLOC-3 complex control a new antimicrobial activity in mouse and human macrophages.
- Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine
Human adipocytes are a source of tissue-regenerative multipotent stem cells.
- Translational and rotational critical-like behaviors in the glass transition of colloidal ellipsoid monolayers
Two critical behaviors in glasses of ellipsoids show thermodynamic and dynamic glass transitions with distinct relaxation.
- Highly sensitive VOC detectors using insect olfactory receptors reconstituted into lipid bilayers
A highly sensitive odorant sensor was developed by using insect olfactory receptors reconstituted into a lipid bilayer membrane.
- Structures of Rhodopseudomonas palustris RC-LH1 complexes with open or closed quinone channels
High-resolution structures of reaction-center light-harvesting 1 complexes provide new insights into quinone dynamics.
- B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8+ tumor-infiltrating lymphocytes
Tumor-targeted T cell costimulatory antibody augments antitumor immunity by enhancing tumor-killing T cells within the tumor.
- O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis
Increased O-GlcNAcylation can confer neuroprotective effects against necroptosis in the context of Alzheimer’s disease.
- Multilayered electronic transfer tattoo that can enable the crease amplification effect
Liquid metal electronic tattoo with the crease amplification effect increases the freedom and accuracy of motion recognition.
- Cell cycle inertia underlies a bifurcation in cell fates after DNA damage
Cells advance through G1 phase for 2 hours after DNA damage, and if not stopped in time, they will enter S phase with damaged DNA.
- Substrate-specific recognition of IKKs mediated by USP16 facilitates autoimmune inflammation
Ubiquitination regulates selective substrate recognition of IKKβ.
- Nonresonant powering of injectable nanoelectrodes enables wireless deep brain stimulation in freely moving mice
Wireless powering of magnetoelectric nanoelectrodes is used for deep brain stimulation in freely moving and transgene-free mice.
- TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation
TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate immune responses to particle-delivered MPLA and CpG.
- Metallic line defect in wide-bandgap transparent perovskite BaSnO3
A metallic line defect is found in wide-bandgap perovskite oxide thin films.
- Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module
The structure of Mediator kinase module reveals its Med12-dependent Cdk8 activation mechanism and an Argonaute-like Med13 protein.
- Oldest cave art found in Sulawesi
An image of a pig painted at least 45,500 years ago on a cave wall in Sulawesi may be the earliest figurative rock art ever found.
- Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer
Discovery of a new HDAC6 inhibitor reveals role for HDAC6 in the regulation of glycolytic metabolism.
- The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex
Dendritic actin networks grow in an autocatalytic manner starting from the uncapped minifilament of dynactin.
- Exceptions to bed-controlled ice sheet flow and retreat from glaciated continental margins worldwide
Geological records of former ice sheets show that behavior cannot be predicted solely from catchment-scale topography and geology.
- The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress
A new method for detecting N-glycosylation reveals a role for the TRAP complex and a mechanism for cell state–specific regulation.
- Abrupt but smaller than expected changes in surface air quality attributable to COVID-19 lockdowns
True air quality improvements during the COVID-19 lockdowns in global cities are more limited than we thought.
- Direct coherent multi-ink printing of fabric supercapacitors
A direct coherent multi-ink writing 3D printing technology constructs coaxial fiber-shaped asymmetric supercapacitors.
- In situ measurements of intracellular thermal conductivity using heater-thermometer hybrid diamond nanosensors
Newly made hybrid nanosensors measured thermal conductivity in cells to be about one-sixth of that in water.
- The Ocean 100: Transnational corporations in the ocean economy
The 100 largest corporations account for 60% of total revenues in eight core ocean economy industries.
- TBC1D3 promotes neural progenitor proliferation by suppressing the histone methyltransferase G9a
A hominoid-specific gene promotes cortical expansion via regulating histone modification.
- Real-time observation and control of optical chaos
Compressive ultrafast photography allows real-time imaging and control of optical chaos phenomena.
- Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization
N-terminal acetylation by NATA acetyltransferase shields many of its targets from inhibitor of apoptosis ubiquitin ligases.
- Integrated quantitative PIXE analysis and EDX spectroscopy using a laser-driven particle source
A laser-driven particle source is exploited for the elemental and stratigraphic characterization of a nonhomogeneous sample.
- EGR1 is a gatekeeper of inflammatory enhancers in human macrophages
The EGR1 transcription factor blunts macrophage activation by coordinating epigenetic repression of inflammatory enhancers.
- Leaf-derived ABA regulates rice seed development via a transporter-mediated and temperature-sensitive mechanism
A leaf-to-caryopsis abscisic acid transport mechanism ensures normal seed development in response to variable temperatures.
- Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types
Massive genetic analysis identifies critical pathways and cell types involved in pathogenesis of amyotrophic lateral sclerosis.
- Deriving iron contents from past and future Venus surface spectra with new high-temperature laboratory emissivity data
Maps of Venus surface composition are possible from orbit.
- CGG repeat RNA G-quadruplexes interact with FMRpolyG to cause neuronal dysfunction in fragile X-related tremor/ataxia syndrome
CGG repeat–derived RNA G-quadruplexes accelerate liquid-to-solid transition of FMRpolyG.
- Optical selection and sorting of nanoparticles according to quantum mechanical properties
Selective manipulation and spectroscopy of single nanoparticles are realized by measuring and controlling quantum resonant forces.
- How volatile components catalyze vapor nucleation
Molecular studies reveal how new particle formation in multicomponent vapors is enhanced by transient hetero-molecular clusters.
Review
- Ancient protein analysis in archaeology
This review synthesizes some of the major advances and applications of ancient protein analysis in the field of archaeology.
Editorial
About The Cover
ONLINE COVER Commercial use of the world's oceans is accelerating, raising concerns as international goals for ocean conservation lag behind. Since transnational corporations (TNCs) act as powerful players in the growing ocean economy and may also be more flexible than government institutions, these huge companies could provide a means to influence positive environmental change. To identify key TNCs, Virdin et al. used data from the Organisation for Economic Co-operation and Development to measure the relative value of ocean-dependent industries to the entire ocean economy, as well as the revenue of individual companies. The researchers identified the top 100 companies across eight ocean industries, which together accounted for 60% of total ocean activity-based revenues in 2018. The findings suggest the outsized influence of a few major TNCs in the ocean economy poses risks to achieving sustainability goals, such as through targeted lobbying to weaken environmental standards. However, these corporations' highly concentrated economic influence may also offer opportunities for greener, more equitable global ocean use, such as through the formation of corporate coalitions that voluntarily commit to sustainability. [CREDIT: G. BRAD LEWIS/SCIENCE SOURCE]
