Research ArticleCELL BIOLOGY

Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine

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Science Advances  13 Jan 2021:
Vol. 7, no. 3, eabd1929
DOI: 10.1126/sciadv.abd1929

Article Information

vol. 7 no. 3

PubMed: 
Online ISSN: 
History: 
  • Received for publication June 16, 2020
  • Accepted for publication November 23, 2020
  • .

Author Information

  1. Avani Yeola1,2,
  2. Shruthi Subramanian1,3,
  3. Rema A. Oliver4,
  4. Christine A. Lucas5,
  5. Julie A. I. Thoms1,2,
  6. Feng Yan6,
  7. Jake Olivier7,
  8. Diego Chacon8,
  9. Melinda L. Tursky9,
  10. Pallavi Srivastava10,
  11. Jason R. Potas11,
  12. Tzongtyng Hung12,
  13. Carl Power12,
  14. Philip Hardy13,
  15. David D. Ma9,
  16. Kristopher A. Kilian10,
  17. Joshua McCarroll14,
  18. Maria Kavallaris14,15,16,
  19. Luke B. Hesson3,17,
  20. Dominik Beck8,
  21. David J. Curtis6,18,
  22. Jason W. H. Wong19,
  23. Edna C. Hardeman5,
  24. William R. Walsh4,
  25. Ralph Mobbs4,20,
  26. Vashe Chandrakanthan1,2,* and
  27. John E. Pimanda1,2,3,21,*
  1. 1Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
  2. 2School of Medical Sciences, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
  3. 3Prince of Wales Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
  4. 4Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Sydney, Sydney, NSW 2052, Australia.
  5. 5Cellular and Genetic Medicine Unit, School of Medical Sciences, UNSW Sydney, Sydney, NSW 2052, Australia.
  6. 6Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia.
  7. 7School of Mathematics and Statistics, UNSW Sydney, Sydney, NSW 2052, Australia.
  8. 8School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia.
  9. 9St. Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital Sydney and St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.
  10. 10School of Material Sciences and Engineering, School of Chemistry, Australian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW 2052, Australia.
  11. 11Translational Neuroscience Facility, School of Medical Sciences, UNSW Sydney, Sydney, NSW 2052, Australia.
  12. 12Biological Resources Imaging Laboratory, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
  13. 13Cyto Labs, Bentley, WA 6102, Australia.
  14. 14Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, Sydney, NSW, Australia.
  15. 15ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW 2052, Australia.
  16. 16School of Women’s and Children’s Health, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
  17. 17Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
  18. 18Department of Clinical Haematology, Alfred Health, Melbourne, VIC, Australia.
  19. 19School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region.
  20. 20Department of Neurosurgery, Prince of Wales Hospital, Randwick, NSW 2031, Australia.
  21. 21Department of Haematology, Prince of Wales Hospital, Randwick, NSW 2031, Australia.
  1. *Corresponding author. Email: v.chandrakanthan{at}unsw.edu.au (V.C); jpimanda{at}unsw.edu.au (J.E.P.)

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