Research ArticleCELL BIOLOGY
Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine
- View ORCID ProfileAvani Yeola1,2,
- View ORCID ProfileShruthi Subramanian1,3,
- View ORCID ProfileRema A. Oliver4,
- Christine A. Lucas5,
- View ORCID ProfileJulie A. I. Thoms1,2,
- View ORCID ProfileFeng Yan6,
- View ORCID ProfileJake Olivier7,
- Diego Chacon8,
- Melinda L. Tursky9,
- View ORCID ProfilePallavi Srivastava10,
- View ORCID ProfileJason R. Potas11,
- View ORCID ProfileTzongtyng Hung12,
- Carl Power12,
- Philip Hardy13,
- David D. Ma9,
- View ORCID ProfileKristopher A. Kilian10,
- View ORCID ProfileJoshua McCarroll14,
- View ORCID ProfileMaria Kavallaris14,15,16,
- Luke B. Hesson3,17,
- Dominik Beck8,
- View ORCID ProfileDavid J. Curtis6,18,
- Jason W. H. Wong19,
- View ORCID ProfileEdna C. Hardeman5,
- View ORCID ProfileWilliam R. Walsh4,
- Ralph Mobbs4,20,
- View ORCID ProfileVashe Chandrakanthan1,2,* and
- View ORCID ProfileJohn E. Pimanda1,2,3,21,*
- 1Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
- 2School of Medical Sciences, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
- 3Prince of Wales Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
- 4Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Sydney, Sydney, NSW 2052, Australia.
- 5Cellular and Genetic Medicine Unit, School of Medical Sciences, UNSW Sydney, Sydney, NSW 2052, Australia.
- 6Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia.
- 7School of Mathematics and Statistics, UNSW Sydney, Sydney, NSW 2052, Australia.
- 8School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia.
- 9St. Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital Sydney and St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.
- 10School of Material Sciences and Engineering, School of Chemistry, Australian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW 2052, Australia.
- 11Translational Neuroscience Facility, School of Medical Sciences, UNSW Sydney, Sydney, NSW 2052, Australia.
- 12Biological Resources Imaging Laboratory, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
- 13Cyto Labs, Bentley, WA 6102, Australia.
- 14Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, Sydney, NSW, Australia.
- 15ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW 2052, Australia.
- 16School of Women’s and Children’s Health, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
- 17Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
- 18Department of Clinical Haematology, Alfred Health, Melbourne, VIC, Australia.
- 19School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region.
- 20Department of Neurosurgery, Prince of Wales Hospital, Randwick, NSW 2031, Australia.
- 21Department of Haematology, Prince of Wales Hospital, Randwick, NSW 2031, Australia.
- ↵*Corresponding author. Email: v.chandrakanthan{at}unsw.edu.au (V.C); jpimanda{at}unsw.edu.au (J.E.P.)
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Science Advances 13 Jan 2021:
Vol. 7, no. 3, eabd1929
DOI: 10.1126/sciadv.abd1929
Vol. 7, no. 3, eabd1929
DOI: 10.1126/sciadv.abd1929
Avani Yeola
1Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
2School of Medical Sciences, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
Shruthi Subramanian
1Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
3Prince of Wales Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
Rema A. Oliver
4Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Sydney, Sydney, NSW 2052, Australia.
Christine A. Lucas
5Cellular and Genetic Medicine Unit, School of Medical Sciences, UNSW Sydney, Sydney, NSW 2052, Australia.
Julie A. I. Thoms
1Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
2School of Medical Sciences, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
Feng Yan
6Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Jake Olivier
7School of Mathematics and Statistics, UNSW Sydney, Sydney, NSW 2052, Australia.
Diego Chacon
8School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia.
Melinda L. Tursky
9St. Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital Sydney and St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.
Pallavi Srivastava
10School of Material Sciences and Engineering, School of Chemistry, Australian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW 2052, Australia.
Jason R. Potas
11Translational Neuroscience Facility, School of Medical Sciences, UNSW Sydney, Sydney, NSW 2052, Australia.
Tzongtyng Hung
12Biological Resources Imaging Laboratory, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
Carl Power
12Biological Resources Imaging Laboratory, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
Philip Hardy
13Cyto Labs, Bentley, WA 6102, Australia.
David D. Ma
9St. Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital Sydney and St Vincent’s Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2010, Australia.
Kristopher A. Kilian
10School of Material Sciences and Engineering, School of Chemistry, Australian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW 2052, Australia.
Joshua McCarroll
14Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, Sydney, NSW, Australia.
Maria Kavallaris
14Children’s Cancer Institute, Lowy Cancer Research Centre, University of New South Wales Sydney, Sydney, NSW, Australia.
15ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Australian Centre for Nanomedicine, UNSW Sydney, Sydney, NSW 2052, Australia.
16School of Women’s and Children’s Health, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
Luke B. Hesson
3Prince of Wales Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
17Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
Dominik Beck
8School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW 2007, Australia.
David J. Curtis
6Australian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne, VIC, Australia.
18Department of Clinical Haematology, Alfred Health, Melbourne, VIC, Australia.
Jason W. H. Wong
19School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region.
Edna C. Hardeman
5Cellular and Genetic Medicine Unit, School of Medical Sciences, UNSW Sydney, Sydney, NSW 2052, Australia.
William R. Walsh
4Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Sydney, Sydney, NSW 2052, Australia.
Ralph Mobbs
4Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, UNSW Sydney, Sydney, NSW 2052, Australia.
20Department of Neurosurgery, Prince of Wales Hospital, Randwick, NSW 2031, Australia.
Vashe Chandrakanthan
1Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
2School of Medical Sciences, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
John E. Pimanda
1Adult Cancer Program, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW 2052, Australia.
2School of Medical Sciences, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
3Prince of Wales Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia.
21Department of Haematology, Prince of Wales Hospital, Randwick, NSW 2031, Australia.
