Research ArticleCELLULAR NEUROSCIENCE

O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis

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Science Advances  13 Jan 2021:
Vol. 7, no. 3, eabd3207
DOI: 10.1126/sciadv.abd3207

Article Information

vol. 7 no. 3

Online ISSN: 
History: 
  • Received for publication June 14, 2020
  • Accepted for publication November 19, 2020
  • .

Author Information

  1. Jinsu Park1,2,
  2. Hee-Jin Ha1,
  3. Eun Seon Chung3,
  4. Seung Hyun Baek1,
  5. Yoonsuk Cho1,
  6. Hark Kyun Kim1,
  7. Jihoon Han1,
  8. Jae Hoon Sul1,
  9. Jeongmi Lee1,
  10. Eunae Kim1,
  11. Junsik Kim1,
  12. Yong Ryoul Yang4,
  13. Mikyoung Park5,
  14. Sung Hyun Kim6,
  15. Thiruma V. Arumugam1,7,
  16. Hyemin Jang8,
  17. Sang Won Seo9,
  18. Pann-Ghill Suh10 and
  19. Dong-Gyu Jo1,2,11,*
  1. 1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
  2. 2Department of Health Science and Technology, Sungkyunkwan University, Seoul 06351, Korea.
  3. 3Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
  4. 4Aging Research Center, Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
  5. 5Center for Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.
  6. 6Department of Physiology, School of Medicine, Kyung Hee University, Seoul 02447, Korea.
  7. 7School of Life Sciences, La Trobe University, Melbourne, Victoria, Australia.
  8. 8Samsung Alzheimer’s Research Center, Samsung Medical Center, Seoul 06351, Korea.
  9. 9Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
  10. 10Korea Brain Research Institute, Daegu 41062, Korea.
  11. 11Biomedical Institute for Convergence, Sungkyunkwan University, Suwon 16419, Korea.
  1. *Corresponding author. Email: jodg{at}skku.edu

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