Research ArticleCELLULAR NEUROSCIENCE
O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis
- View ORCID ProfileJinsu Park1,2,
- Hee-Jin Ha1,
- View ORCID ProfileEun Seon Chung3,
- Seung Hyun Baek1,
- Yoonsuk Cho1,
- View ORCID ProfileHark Kyun Kim1,
- Jihoon Han1,
- Jae Hoon Sul1,
- View ORCID ProfileJeongmi Lee1,
- View ORCID ProfileEunae Kim1,
- Junsik Kim1,
- Yong Ryoul Yang4,
- Mikyoung Park5,
- View ORCID ProfileSung Hyun Kim6,
- View ORCID ProfileThiruma V. Arumugam1,7,
- View ORCID ProfileHyemin Jang8,
- View ORCID ProfileSang Won Seo9,
- Pann-Ghill Suh10 and
- View ORCID ProfileDong-Gyu Jo1,2,11,*
- 1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
- 2Department of Health Science and Technology, Sungkyunkwan University, Seoul 06351, Korea.
- 3Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
- 4Aging Research Center, Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
- 5Center for Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.
- 6Department of Physiology, School of Medicine, Kyung Hee University, Seoul 02447, Korea.
- 7School of Life Sciences, La Trobe University, Melbourne, Victoria, Australia.
- 8Samsung Alzheimer’s Research Center, Samsung Medical Center, Seoul 06351, Korea.
- 9Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
- 10Korea Brain Research Institute, Daegu 41062, Korea.
- 11Biomedical Institute for Convergence, Sungkyunkwan University, Suwon 16419, Korea.
- ↵*Corresponding author. Email: jodg{at}skku.edu
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Science Advances 13 Jan 2021:
Vol. 7, no. 3, eabd3207
DOI: 10.1126/sciadv.abd3207
Vol. 7, no. 3, eabd3207
DOI: 10.1126/sciadv.abd3207
Jinsu Park
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
2Department of Health Science and Technology, Sungkyunkwan University, Seoul 06351, Korea.
Hee-Jin Ha
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Eun Seon Chung
3Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
Seung Hyun Baek
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Yoonsuk Cho
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Hark Kyun Kim
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Jihoon Han
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Jae Hoon Sul
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Jeongmi Lee
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Eunae Kim
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Junsik Kim
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Yong Ryoul Yang
4Aging Research Center, Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Mikyoung Park
5Center for Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Korea.
Sung Hyun Kim
6Department of Physiology, School of Medicine, Kyung Hee University, Seoul 02447, Korea.
Thiruma V. Arumugam
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
7School of Life Sciences, La Trobe University, Melbourne, Victoria, Australia.
Hyemin Jang
8Samsung Alzheimer’s Research Center, Samsung Medical Center, Seoul 06351, Korea.
Sang Won Seo
9Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.
Pann-Ghill Suh
10Korea Brain Research Institute, Daegu 41062, Korea.
Dong-Gyu Jo
1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
2Department of Health Science and Technology, Sungkyunkwan University, Seoul 06351, Korea.
11Biomedical Institute for Convergence, Sungkyunkwan University, Suwon 16419, Korea.
