Research ArticleIMMUNOLOGY

TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation

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Science Advances  13 Jan 2021:
Vol. 7, no. 3, eabd4235
DOI: 10.1126/sciadv.abd4235

Article Information

vol. 7 no. 3

PubMed: 
Online ISSN: 
History: 
  • Received for publication June 19, 2020
  • Accepted for publication November 18, 2020
  • .

Author Information

  1. P. Pradhan1,2,3,*,
  2. R. Toy1,*,
  3. N. Jhita4,
  4. A. Atalis1,
  5. B. Pandey1,
  6. A. Beach1,
  7. E. L. Blanchard1,
  8. S. G. Moore2,
  9. D. A. Gaul2,
  10. P. J. Santangelo1,
  11. D. M. Shayakhmetov4,5 and
  12. K. Roy1,2,3,
  1. 1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
  2. 2The Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.
  3. 3Marcus Center for Therapeutic Cell Characterization and Manufacturing, Georgia Institute of Technology, Atlanta, GA, USA.
  4. 4Lowance Center of Human Immunology, Department of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, GA, USA.
  5. 5Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
  1. Corresponding author. Email: krish.roy{at}gatech.edu
  • * These authors contributed equally to this work.

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