TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation

P. Pradhan; R. Toy; N. Jhita; A. Atalis; B. Pandey; A. Beach; E. L. Blanchard; S. G. Moore; D. A. Gaul; P. J. Santangelo; D. M. Shayakhmetov; K. Roy

doi:10.1126/sciadv.abd4235

Research ArticleIMMUNOLOGY

TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation

View ORCID ProfileP. Pradhan¹,²,³,*,
View ORCID ProfileR. Toy¹,*,
View ORCID ProfileN. Jhita⁴,
View ORCID ProfileA. Atalis¹,
View ORCID ProfileB. Pandey¹,
A. Beach¹,
E. L. Blanchard¹,
View ORCID ProfileS. G. Moore²,
View ORCID ProfileD. A. Gaul²,
View ORCID ProfileP. J. Santangelo¹,
View ORCID ProfileD. M. Shayakhmetov⁴,⁵ and
View ORCID ProfileK. Roy ¹,²,³,†

¹The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
²The Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.
³Marcus Center for Therapeutic Cell Characterization and Manufacturing, Georgia Institute of Technology, Atlanta, GA, USA.
⁴Lowance Center of Human Immunology, Department of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, GA, USA.
⁵Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.

↵†Corresponding author. Email: krish.roy{at}gatech.edu

↵* These authors contributed equally to this work.

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Science Advances 13 Jan 2021:
Vol. 7, no. 3, eabd4235
DOI: 10.1126/sciadv.abd4235

P. Pradhan

1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

2The Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.

3Marcus Center for Therapeutic Cell Characterization and Manufacturing, Georgia Institute of Technology, Atlanta, GA, USA.

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R. Toy

1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

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N. Jhita

4Lowance Center of Human Immunology, Department of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, GA, USA.

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A. Atalis

1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

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B. Pandey

1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

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A. Beach

1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

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E. L. Blanchard

1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

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S. G. Moore

2The Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.

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D. A. Gaul

2The Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.

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P. J. Santangelo

1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

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D. M. Shayakhmetov

4Lowance Center of Human Immunology, Department of Pediatrics and Medicine, Emory University School of Medicine, Atlanta, GA, USA.

5Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.

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K. Roy

1The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

2The Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.

3Marcus Center for Therapeutic Cell Characterization and Manufacturing, Georgia Institute of Technology, Atlanta, GA, USA.

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For correspondence: krish.roy@gatech.edu

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TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation

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