Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging

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Science Advances  21 Jul 2021:
Vol. 7, no. 30, eabg5733
DOI: 10.1126/sciadv.abg5733

Article Information

vol. 7 no. 30

Online ISSN: 
  • Received for publication January 24, 2021
  • Accepted for publication June 4, 2021
  • .

Author Information

  1. Csaba Adori1,*,
  2. Teresa Daraio2,
  3. Raoul Kuiper3,
  4. Swapnali Barde1,
  5. Lubica Horvathova4,
  6. Takashi Yoshitake5,
  7. Robert Ihnatko6,,
  8. Ismael Valladolid-Acebes2,
  9. Pauline Vercruysse2,
  10. Ashley M. Wellendorf7,
  11. Roberto Gramignoli3,
  12. Bela Bozoky8,
  13. Jan Kehr5,
  14. Elvar Theodorsson6,
  15. Jose A. Cancelas7,9,
  16. Boris Mravec4,10,
  17. Carl Jorns11,
  18. Ewa Ellis12,
  19. Jan Mulder1,
  20. Mathias Uhlén1,13,,
  21. Christina Bark1, and
  22. Tomas Hökfelt1,
  1. 1Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.
  2. 2The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden.
  3. 3Department of Laboratory Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.
  4. 4Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
  5. 5Department of Physiology and Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden.
  6. 6Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, 58285 Linköping, Sweden.
  7. 7Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
  8. 8Department of Clinical Pathology/Cytology, Karolinska University Hospital, Huddinge, Sweden.
  9. 9Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0055, USA.
  10. 10Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Slovak Republic.
  11. 11PO Transplantation, Karolinska University Hospital Huddinge, 141 52 Stockholm, Sweden.
  12. 12Department of Transplantation Surgery and Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska University Hospital, Karolinska Institutet, 17177 Stockholm, Sweden.
  13. 13Science for Life Laboratory, Royal Institute of Technology, 10691 Stockholm, Sweden.
  1. *Corresponding author. Email: adorics{at}
  • Present address: Institute of Pathology, University Medical Center, Georg-August University of Göttingen, Göttingen, Germany.

  • These authors contributed equally to this work.


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