Research ArticleBIOPHYSICS

Confinement-induced self-organization in growing bacterial colonies

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Science Advances  22 Jan 2021:
Vol. 7, no. 4, eabc8685
DOI: 10.1126/sciadv.abc8685

Abstract

We investigate the emergence of global alignment in colonies of dividing rod-shaped cells under confinement. Using molecular dynamics simulations and continuous modeling, we demonstrate that geometrical anisotropies in the confining environment give rise to an imbalance in the normal stresses, which, in turn, drives a collective rearrangement of the cells. This behavior crucially relies on the colony’s solid-like mechanical response at short time scales and can be recovered within the framework of active hydrodynamics upon modeling bacterial colonies as growing viscoelastic gels characterized by Maxwell-like stress relaxation.

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