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1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer

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Science Advances  20 Jan 2021:
Vol. 7, no. 4, eabe1174
DOI: 10.1126/sciadv.abe1174

Article Information

vol. 7 no. 4

PubMed: 
Online ISSN: 
History: 
  • Received for publication July 31, 2020
  • Accepted for publication December 3, 2020
  • .

Author Information

  1. Marisa K. Kilgour1,2,
  2. Sarah MacPherson2,
  3. Lauren G. Zacharias3,
  4. Abigail E. Ellis4,
  5. Ryan D. Sheldon4,
  6. Elaine Y. Liu2,
  7. Sarah Keyes1,
  8. Brenna Pauly1,
  9. Gillian Carleton1,2,
  10. Bertrand Allard5,6,7,
  11. Julian Smazynski1,2,
  12. Kelsey S. Williams4,
  13. Peter H. Watson2,8,
  14. John Stagg5,6,7,
  15. Brad H. Nelson1,2,9,
  16. Ralph J. DeBerardinis3,10,
  17. Russell G. Jones4,
  18. Phineas T. Hamilton2,* and
  19. Julian J. Lum1,2,*,
  1. 1Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
  2. 2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
  3. 3Children’s Research Institute, UT Southwestern, Dallas, TX, USA.
  4. 4Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
  5. 5Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Québec, Canada.
  6. 6Faculté de Pharmacie, Université de Montréal, Québec, Canada.
  7. 7Institut du Cancer de Montréal, Québec, Canada.
  8. 8Biobanking and Biospecimen Research Services, Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
  9. 9Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
  10. 10Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA.
  1. Corresponding author. Email: jjlum{at}bccancer.bc.ca
  • * These authors contributed equally to this work.

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