Research ArticleCANCER
1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer
- View ORCID ProfileMarisa K. Kilgour1,2,
- Sarah MacPherson2,
- Lauren G. Zacharias3,
- View ORCID ProfileAbigail E. Ellis4,
- Ryan D. Sheldon4,
- Elaine Y. Liu2,
- Sarah Keyes1,
- Brenna Pauly1,
- View ORCID ProfileGillian Carleton1,2,
- Bertrand Allard5,6,7,
- Julian Smazynski1,2,
- View ORCID ProfileKelsey S. Williams4,
- View ORCID ProfilePeter H. Watson2,8,
- View ORCID ProfileJohn Stagg5,6,7,
- View ORCID ProfileBrad H. Nelson1,2,9,
- View ORCID ProfileRalph J. DeBerardinis3,10,
- View ORCID ProfileRussell G. Jones4,
- Phineas T. Hamilton2,* and
- View ORCID ProfileJulian J. Lum1,2,*,†
- 1Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
- 2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
- 3Children’s Research Institute, UT Southwestern, Dallas, TX, USA.
- 4Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
- 5Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Québec, Canada.
- 6Faculté de Pharmacie, Université de Montréal, Québec, Canada.
- 7Institut du Cancer de Montréal, Québec, Canada.
- 8Biobanking and Biospecimen Research Services, Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
- 9Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
- 10Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA.
- ↵†Corresponding author. Email: jjlum{at}bccancer.bc.ca
↵* These authors contributed equally to this work.
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Science Advances 20 Jan 2021:
Vol. 7, no. 4, eabe1174
DOI: 10.1126/sciadv.abe1174
Vol. 7, no. 4, eabe1174
DOI: 10.1126/sciadv.abe1174
Marisa K. Kilgour
1Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
Sarah MacPherson
2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
Lauren G. Zacharias
3Children’s Research Institute, UT Southwestern, Dallas, TX, USA.
Abigail E. Ellis
4Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Ryan D. Sheldon
4Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Elaine Y. Liu
2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
Sarah Keyes
1Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Brenna Pauly
1Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Gillian Carleton
1Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
Bertrand Allard
5Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Québec, Canada.
6Faculté de Pharmacie, Université de Montréal, Québec, Canada.
7Institut du Cancer de Montréal, Québec, Canada.
Julian Smazynski
1Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
Kelsey S. Williams
4Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Peter H. Watson
2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
8Biobanking and Biospecimen Research Services, Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
John Stagg
5Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Québec, Canada.
6Faculté de Pharmacie, Université de Montréal, Québec, Canada.
7Institut du Cancer de Montréal, Québec, Canada.
Brad H. Nelson
1Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
9Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Ralph J. DeBerardinis
3Children’s Research Institute, UT Southwestern, Dallas, TX, USA.
10Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Russell G. Jones
4Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Phineas T. Hamilton
2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
Julian J. Lum
1Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
2Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.
