Contents
January 2021
Vol 7, Issue 5
Vol 7, Issue 5
Contents
Research Articles
- A thermal activated and differential self-calibrated flexible epidermal biomicrofluidic device for wearable accurate blood glucose monitoring
A self-calibrated flexible epidermal biomicrofluidic device is proposed for wearable accurate blood glucose monitoring.
- Keratinocytes control skin immune homeostasis through de novo–synthesized glucocorticoids
Keratinocytes control tissue homeostasis and skin inflammation via immunosuppressive glucocorticoids.
- Gyroresonant wave-particle interactions with chorus waves during extreme depletions of plasma density in the Van Allen radiation belts
Periods of low plasma density allow chorus waves to accelerate radiation belt electrons to ultrarelativistic energies.
- Moonstruck sleep: Synchronization of human sleep with the moon cycle under field conditions
Sleep is delayed and shortened preceding the full moon phase, both in absence of electric light and in modern urban societies.
- Anisotropic electrostatic screening of charged colloids in nematic solvents
Anisotropic electrostatic screening in charged nematic colloids is demonstrated using a combination of theory and experiments.
- Spatially resolved 3D metabolomic profiling in tissues
Spatially resolved metabolic profiling and isotope-tagged protein analysis revealed unique lipid distributions in tissues.
- Bandwidth-unlimited polarization-maintaining metasurfaces
A general method of designing polarization and angular nondispersive metasurface with unlimited bandwidth is provided.
- EphrinB2 clustering by Nipah virus G is required to activate and trap F intermediates at supported lipid bilayer–cell interfaces
The reconstitution of Nipah virus fusion activation provides new insights into the dynamics of the viral entry glycoproteins.
- Women temporarily synchronize their menstrual cycles with the luminance and gravimetric cycles of the Moon
Women can synchronize their menstrual cycles with the Moon.
- Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases
Engineered model of the human gut-liver-brain axis can be used to study the link between the microbiome and Parkinson’s disease.
- Thermal squeezing of the seismogenic zone controlled rupture of the volcano-rooted Flores Thrust
Volcanic heating of a tectonic fault changed the way it produces large earthquakes.
- Regulation of tumor immune suppression and cancer cell survival by CXCL1/2 elevation in glioblastoma multiforme
CXCL1/2, elevated in GBM to promote tumor progression, hold potential as clinical targets in GBM treatment.
- Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer
Historically well-known tumor-promoting gene family plays a key role in cell identity regulation in small cell lung cancer.
- Layer- and gate-tunable spin-orbit coupling in a high-mobility few-layer semiconductor
Rashba spin-orbit coupling in atomically thin InSe is varied layer by layer and by tuning out-of-plane electric field.
- Improper molecular ferroelectrics with simultaneous ultrahigh pyroelectricity and figures of merit
The coupling between the rotation angle of anions and polarization yields colossal pyroelectricity of molecular ferroelectrics.
- Amorphization in extreme deformation of the CrMnFeCoNi high-entropy alloy
Extreme deformation of high-entropy alloys increases toughness by converting crystalline structures to amorphous zones.
- Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells
KLF11 is a negative regulator of CSC stemness in sarcoma by repressing YAP/TEAD-dependent transcription.
- Extensive tissue-specific expression variation and novel regulators underlying circadian behavior
A dataset of >700 tissue-specific transcriptomes of D. melanogaster reveals population-level molecular circadian clock variation.
- Coherent control of collective nuclear quantum states via transient magnons
A collective nuclear state is coherently controlled via a solid’s quasi-particle with zeptosecond precision.
- Tdp1 protects from topoisomerase 1–mediated chromosomal breaks in adult zebrafish but is dispensable during larval development
The repair of protein-linked chromosomal breaks requires distinct factors throughout the life span.
- Meta-optics achieves RGB-achromatic focusing for virtual reality
A large dispersion-engineered metalens achieves multicolor focusing and opens a path to a future virtual reality platform.
- Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation
Dissection of the HPA axis using single-cell RNA sequencing uncovers adrenal ABCB1 as an important player of stress adaptation.
- Anti–Na+/K+-ATPase immunotherapy ameliorates α-synuclein pathology through activation of Na+/K+-ATPase α1–dependent autophagy
Activation of NKAα1-dependent autophagy ameliorates α-synuclein pathology.
- The structure of the actin filament uncapping complex mediated by twinfilin
Competitive interactions between capping protein, twinfilin, and actin drive actin filament uncapping and recycling.
- Lewis acid–catalyzed domino generation/[2,3]-sigmatropic rearrangement of ammonium ylides to access chiral azabicycles
A domino process to prepare chiral azabicycles with bridgehead quaternary stereogenic centers is reported.
- Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism
Crystal structures of NTSR1 bound to agonists, inverse agonists, and in the apo state enabled by a novel fusion to DARPin D12.
- The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction
Keratin defects associated with blistering skin diseases alter force transmission to the nucleus.
- Mechanism of C-type inactivation in the hERG potassium channel
C-type inactivation in hERG is associated with an asymmetrical constricted-like conformation of the selectivity filter.
- Asymptotic turbulent friction in 2D rough-walled flows
In turbulent rough-walled flows, the 2D friction-roughness relation differs from its 3D counterpart.
- Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox
Saturated fat breaks down less during sudden illnesses, resulting in lower monomer concentrations, and reducing disease severity.
- Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ
Structural and biochemical evidence resolves previous contradictory findings for heme-dependent NCoR recruitment to REV-ERBβ.
- Microbiota control of maternal behavior regulates early postnatal growth of offspring
Microbiota control of maternal behavior regulates early postnatal growth of offspring.
- SINGLE: Atomic-resolution structure identification of nanocrystals by graphene liquid cell EM
Algorithms for atomic-resolution 3D reconstruction of nanocrystals imaged in solution with electron microscopy are introduced.
- Fibrillin-1–enriched microenvironment drives endothelial injury and vascular rarefaction in chronic kidney disease
The study illustrates a crucial role of tissue microenvironment in mediating endothelial dropout and vascular rarefaction.
- Solar-assisted fabrication of large-scale, patternable transparent wood
Patternable transparent wood with a high transmittance is fabricated via a solar-assisted chemical brushing approach.
- Radiation-induced eosinophils improve cytotoxic T lymphocyte recruitment and response to immunotherapy
Eosinophil can be considered as a mechanistically relevant biomarker for predicting the effectiveness of radio-immunotherapy.
- Orographic evolution of northern Tibet shaped vegetation and plant diversity in eastern Asia
Orogenesis in northern Tibet determines the vegetation and plant diversity of eastern Asia by intensifying winter precipitation.
- A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics
A CRISPR-Cas–driven positive feedback circuit with exponential dynamic enables ultrasensitive detection of genomic DNA.
- Architecture and regulation of an enterobacterial cellulose secretion system
Structural snapshots decipher nucleotide dependence, asymmetry, and polymerization in the enterobacterial cellulose secretion.
- An electronic proton-trapping ion pump for selective drug delivery
Proton-trapping electrodes in the OEIP enhance selective electrophoretic delivery of γ-aminobutyric acid (GABA) neurotransmitter.
- Experimental taphonomy of organelles and the fossil record of early eukaryote evolution
Taphonomy experiments reveal the potential for a fossil record of the origin of complex life.
- Nondestructive, high-resolution, chemically specific 3D nanostructure characterization using phase-sensitive EUV imaging reflectometry
A new imaging technique enables nondestructive, 3D characterization of nanostructures, their composition, and interfaces.
- Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencing
Lung adenocarcinoma manifesting as radiological subsolid nodules has distinct cell composition within its tumor microenvironment.
- A 3D disease and regeneration model of peripheral nervous system–on–a–chip
A 3D PNS disease–on–a–chip enables the monitoring of pathophysiological processes, including demyelination and remyelination.
- NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia
UBR7 supports nucleotide biosynthesis and NOTCH1-driven T cell acute lymphoblastic leukemia through regulation of PRPS enzymes.
- A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues
A mechanogenetic system was developed using a synthetic gene circuit to produce biologic drugs in response to mechanical loading.
- A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action
An oligoamidine with two bacteria-specific mechanisms of action showed broad-spectrum, resistance-resistant antimicrobial effect.
About The Cover
ONLINE COVER The question of whether lunar cycles affect human cycles, including menstruation and sleep, has remained controversial and largely unanswered. Helfrich-Förster et al. analyzed long-term menstrual cycle records kept by 22 women for up to 32 years, finding that women with cycles lasting longer than 27 days intermittently synchronized with cycles that affect the intensity of moonlight and the moon's gravitational pull. This synchrony was lost as women aged and when they were exposed to artificial light at night. The researchers hypothesized that human reproductive behavior may have been synchronous with the moon during ancient times, but that this changed as modern lifestyles emerged and humans increasingly gained exposure to artificial light at night. In another study, Casiraghi et al. explored the moon's effect on human sleep and nighttime wakefulness by measuring wake/sleep cycles in three indigenous Argentinian Toba/Qom communities with varying access to electricity. Across all communities, sleep patterns were clearly modulated by the moon's cycle. Participants went to sleep the latest and slept the least 3 to 5 days before the night of a full moon. The researchers also analyzed sleep recordings from University of Washington undergraduate students, unexpectedly finding moon-dependent sleep patterns in this large urban environment similar to those of the Toba/Qom communities. The findings suggest that human sleep is synchronized with the moon's phases regardless of ethnic or cultural differences—and even in locations where light pollution outshines moonlight. [CREDIT: JOEL SHARPE/GETTY IMAGES]
