Noninvasive imaging and quantification of bile salt hydrolase activity: From bacteria to humans

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Science Advances  03 Feb 2021:
Vol. 7, no. 6, eaaz9857
DOI: 10.1126/sciadv.aaz9857

Article Information

vol. 7 no. 6

Online ISSN: 
  • Received for publication October 25, 2019
  • Accepted for publication December 16, 2020
  • .

Author Information

  1. Pavlo V. Khodakivskyi1,2,
  2. Christian L. Lauber2,*,
  3. Aleksey Yevtodiyenko2,
  4. Arkadiy A. Bazhin2,
  5. Stephen Bruce3,
  6. Tamar Ringel-Kulka4,
  7. Yehuda Ringel5,6,7,
  8. Bertrand Bétrisey8,
  9. Joana Torres9,10,
  10. Jianzhong Hu11,
  11. Chieh Jason Chou12 and
  12. Elena A. Goun1,2,
  1. 1Department of Chemistry, University of Missouri, Columbia, MO 65211, USA.
  2. 2Institute of Chemical Sciences and Engineering (ISIC), Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
  3. 3Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
  4. 4UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599, USA.
  5. 5Division of Gastroenterology and Hepatology, Meir Medical Center, affiliated with Tel Aviv University, Kfar-Saba, Israel.
  6. 6Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
  7. 7Biomica Ltd. 13 Gad Feinstein St. POB 4173, Rehovot 7414002, Israel.
  8. 8Cellular Metabolism, Department of Cell Biology, Nestlé Institute of Health Sciences, Nestlé Research, 1000 Lausanne, Switzerland.
  9. 9Gastroenterology Division, Hospital Beatriz Ângelo, Loures, Portugal.
  10. 10The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA.
  11. 11Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  12. 12Department of Gastro-Intestinal Health and Microbiome, Nestlé Institute of Health Sciences, Nestlé Research, 1000 Lausanne, Switzerland.
  1. Correspondence author. Email: elena.goun{at}
  • * Present address: Institute for Genomic Medicine, Nationwide Children’s Hospital, Columbus, OH 43215, USA.


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