A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting

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Science Advances  05 Feb 2021:
Vol. 7, no. 6, eaba0776
DOI: 10.1126/sciadv.aba0776

Article Information

vol. 7 no. 6

Online ISSN: 
  • Received for publication November 3, 2019
  • Accepted for publication December 21, 2020
  • .

Author Information

  1. Yanmei He1,*,
  2. Lei Lei1,2,*,
  3. Jun Cao1,3,,
  4. Xiaotong Yang2,
  5. Shengsheng Cai1,
  6. Fan Tong2,
  7. Dennis Huang3,
  8. Heng Mei1,
  9. Kui Luo4,
  10. Huile Gao2,,
  11. Bin He1 and
  12. Nicholas A. Peppas3,5,
  1. 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, P. R. China.
  2. 2West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China.
  3. 3Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78731, USA.
  4. 4Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
  5. 5Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78731, USA.
  1. Corresponding author. Email: caojun{at} (J.C.); gaohuile{at} (H.G.); peppas{at} (N.A.P.)
  • * These authors equally contributed to this work.


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