Research ArticleCANCER

Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle

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Science Advances  12 Feb 2021:
Vol. 7, no. 7, eabd2645
DOI: 10.1126/sciadv.abd2645

Article Information

vol. 7 no. 7

PubMed: 
Online ISSN: 
History: 
  • Received for publication June 10, 2020
  • Accepted for publication December 24, 2020
  • .

Author Information

  1. Yool Lee1,*,
  2. Shi Yi Fong1,
  3. Joy Shon1,
  4. Shirley L. Zhang1,
  5. Rebekah Brooks2,3,
  6. Nicholas F. Lahens4,
  7. Dechun Chen1,
  8. Chi Van Dang5,3,
  9. Jeffrey M. Field6 and
  10. Amita Sehgal1,
  1. 1Howard Hughes Medical Institute, Chronobiology and Sleep Institute (CSI), Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. 2Cell and Molecular Biology Graduate Group (CAMB), University of Pennsylvania, Philadelphia, PA 19104, USA.
  3. 3The Wistar Institute, Philadelphia, PA 19104, USA.
  4. 4Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  5. 5Ludwig Institute for Cancer Research, New York, NY 10017, USA.
  6. 6Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  1. Corresponding author. Email: amita{at}pennmedicine.upenn.edu
  • * Present address: Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.

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Feb 20212413318952
Mar 202174604264
Apr 202116350103
May 202122318112
Jun 20212217274

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