Research ArticleBIOENGINEERING

Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs

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Science Advances  24 Feb 2021:
Vol. 7, no. 9, eabd6740
DOI: 10.1126/sciadv.abd6740

Article Information

vol. 7 no. 9

PubMed: 
Online ISSN: 
History: 
  • Received for publication July 5, 2020
  • Accepted for publication January 11, 2021
  • .

Author Information

  1. Yan Li1,2,*,
  2. Xin Chen3,*,
  3. Ronghua Jin3,
  4. Lu Chen1,
  5. Ming Dang4,
  6. Hao Cao5,
  7. Yun Dong5,
  8. Bolei Cai2,
  9. Guo Bai1,
  10. J. Justin Gooding6,
  11. Shiyu Liu7,
  12. Duohong Zou1,,
  13. Zhiyuan Zhang1, and
  14. Chi Yang1,
  1. 1National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Department of Oral Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
  2. 2State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, China.
  3. 3School of Chemical Engineering and Technology, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, Xi’an Jiao Tong University, Xi’an 710049, China.
  4. 4School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA.
  5. 5Department of Cardiac Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
  6. 6School of Chemistry, Australian Centre for NanoMedicine and ARC Australian, Centre of Excellence in Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney 2052, Australia.
  7. 7Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China.
  1. Corresponding author. Email: yangchi63{at}hotmail.com (C.Y.); zhzhy0502{at}163.com (Z.Z.); zdhyy{at}ahmu.edu.cn (D.Z.)
  • * These authors contributed equally to this work.

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