Research ArticleNEUROPHYSIOLOGY

Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

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Science Advances  26 Feb 2021:
Vol. 7, no. 9, eabf4100
DOI: 10.1126/sciadv.abf4100

Article Information

vol. 7 no. 9

PubMed: 
Online ISSN: 
History: 
  • Received for publication October 24, 2020
  • Accepted for publication January 14, 2021
  • .

Author Information

  1. Garron T. Dodd1,2,*,,,
  2. Seung Jae Kim1,2,*,
  3. Mathieu Méquinion1,3,
  4. Chrysovalantou E. Xirouchaki1,2,
  5. Jens C. Brüning4,5,6,7,
  6. Zane B. Andrews1,3 and
  7. Tony Tiganis1,2,8,9,,
  1. 1Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
  2. 2Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
  3. 3Department of Physiology, Monash University, VIC 3800, Australia.
  4. 4Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, Gleueler Str. 50, 50931 Cologne, Germany.
  5. 5Center for Endocrinology, Diabetes, and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Str. 26, 50924 Cologne, Germany.
  6. 6Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
  7. 7National Center for Diabetes Research (DZD), Ingolstädter Land Str. 1, 85764 Neuherberg, Germany.
  8. 8Monash Metabolic Phenotyping Facility, Monash University, VIC, Australia.
  9. 9Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.
  1. Corresponding author. Email: garron.dodd{at}unimelb.edu.au (G.T.D.); tony.tiganis{at}monash.edu (T.T.)
  • * These authors contributed equally to this work.

  • Present address: Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3010, Australia.

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