Science Advances

Supplementary Materials

This PDF file includes:

  • Materials and Methods
  • Fig. S1. S-HDL’s biodistribution in atherosclerotic and wild-type mice.
  • Fig. S2. Targeting dynamics of S-HDL to blood Ly-6Chigh monocytes and their expression of key recruitment proteins.
  • Fig. S3. Procedure for in vivo DE-MRI.
  • Fig. S4. Latex bead–based method for tracking macrophage emigration.
  • Fig. S5. Quantification of apoptosis in aortic roots after S-HDL treatment.
  • Fig. S6. Designing a two-step treatment regimen.
  • Fig. S7. Representative binary masks of histological images.
  • Fig. S8. Blood chemistry results.
  • Fig. S9. Plaque size changes during the 9-week treatment.
  • Fig. S10. Changes in macrophage-to-collagen ratio during the 9-week treatment.
  • Fig. S11. Quantification of proliferating macrophages at weeks 1 and 9 of the treatment.
  • Fig. S12. Inflammatory gene expression during the 9-week treatment.

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