Science Advances

Supplementary Materials

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  • Fig. S1. ABC selectively kills HTLV-1–infected and ATL cell lines.
  • Fig. S2. Cell counting assays showing ABC cytotoxicity to MT-2 cells.
  • Fig. S3. ABC-induced apoptosis.
  • Fig. S4. Relative sensitivities to six NRTIs of DT40 cells deficient in the indicated gene.
  • Fig. S5. The relative sensitivity of candidate gene-deficient DT40 cells to the six individual NRTIs and the level of the mRNA expression in ATL cells.
  • Fig. S6. Ectopic expression of TDP1WT, TDP1H263A, and TDP1H493R in MT-2 cells. Fig. S7. ABC and AZT cytotoxicity in MT-2/TDP1WT cells.
  • Fig. S8. CPT11 and veliparib enhance the lethality of ABC on ATL cells.
  • Table S1. Inhibitory concentration (IC50) values of ABC for each cell line.
  • Table S2. Isogenic mutant chicken DT40 cell lines used in this study.
  • Table S3. Characteristics of two ATL patients.
  • Table S4. List of HTLV-1–infected and ATL cell lines.
  • References (48–84)

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