Science Advances

This PDF file includes:

• Fig. S1. Comparison of the BDQ-free M. phlei c-ring ion-binding site with the c-ring ion-binding site from F. nucleatum.
• Fig. S2. Comparison of c-ring surface and electrostatic potential distribution.
• Fig. S3. Structural alignment and comparison of BDQ binding on the c-rings of a non-mycobacterial bacterium (I. tartaricus) and a eukaryotic, human homolog model (S. cerevisiae).
• Fig. S4. Comparison of the protein-bound and soluble, energy-minimized BDQ conformation.
• Table S1. BDQ minimum inhibitory concentrations.
• Table S2. Interactions of BDQ with surrounding amino acid residues and water molecules.
• Legend for movies S1 and S2
• References (52, 53)

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Other Supplementary Material for this manuscript includes the following:

• Movie S1. Morph between the BDQ-free and BDQ-bound M. phlei c-ring structures viewed from the membrane.
• Movie S2. Morph between the BDQ-free and BDQ-bound M. phlei c-ring structures viewed from the cytoplasm.