Science Advances

Supplementary Materials

This PDF file includes:

  • Complete description of ISES reporting enzymes; synthetic procedures and full spectral characterization for synthetic intermediates, chiral HPLC traces used to determine enantiopurity of all HKR products, step height analysis from the Co-salen x-ray crystal structures (93 pages).
  • Fig. S1. Enantioselectivity of the new KRED-119 reporting enzyme.
  • Fig. S2. Enantioselectivity of the new KRED-107 reporting enzyme.
  • Fig. S3. Enantioselectivity of the new KRED-23 reporting enzyme.
  • Fig. S4. Geometric parameters used to estimate step height for the carbafructopyranose-based Co-salen complexes.
  • Fig. S5. Step heights from x-ray crystal structures of the carbafructopyranose-based Co-salen complexes.
  • Table S1. HRMS characterization of Co(III)-salen catalysts.
  • Table S2. HKR under standard "round bottom flask conditions" with Co(III)-salen-3,5-DNB complexes.

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