Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. The amino acid sequences of AncAmphibian-359 and frog-423.
  • Fig. S2. A composite phylogenetic tree of 14 representative SWS1 pigments.
  • Fig. S3. The tertiary structure of AncAmphibian-359.
  • Fig. S4. Evolutionary patterns of TM replacements in AncAmphibian-359.
  • Table S1. Ancestral amino acids with PPs (in parentheses) inferred using PAML with JTT and WAG models.
  • Table S2. TM changes and associated λmax, Δλmax, θ, and θ0 (Δλmax values at the highest levels of epistatic interactions without individual effects) in AncAmphibian-359.
  • Table S3. The λmax shifts of chimeric mutants caused by various TM replacements that were preceded by other TM replacements.
  • Table S4. Epistatic evolution of A251643F.

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