Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Whisker plot distribution of genomic and metagenomic PFam3599 protein hits to various hidden Markov profiles.
  • Fig. S2. Distribution of HgcA and WL pathway–associated CFeSP encoding genes in methanogenic Archaea.
  • Fig. S3. Distribution of HgcA, HgcB, and WL pathway–associated CFeSP in genomes of Deltaproteobacteria and Firmicutes.
  • Fig. S4. Hg methylation assays for M. luminyensis B10.
  • Fig. S5. Repeat methylation assay for M. luminyensis B10.
  • Fig. S6. Schematic representation of the domain architectures of HgcA, HgcB, and the fusion HgcAB.
  • Fig. S7. Hg methylation assays for P. furiosus.
  • Fig. S8. MEGAN-based co-occurrence profiles of the closest genera-assigned HgcAs based on all metagenomes.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). List of metagenomic projects with hgcA counts.
  • Table S2 (Microsoft Excel format). Identity matrix of sequence similarities.

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