Science Advances

Supplementary Materials

This PDF file includes:

  • Materials and Methods
  • Fig. S1. Functional analysis of prmt8 using zebrafish.
  • Fig. S2. Quantitative analysis of the gait abnormalities in the prmt8−/− mice.
  • Fig. S3. Interaction of PRMT8-Flag and mammalian PLDs.
  • Fig. S4. Organizations of the catalytic domains in PLD superfamily.
  • Fig. S5. Dimerization of PRMT8-Flag wild-type (WT) and K107R and G121A mutants.
  • Fig. S6. Measuring vertebrate PRMT8 paralog-derived products from PC by MALDI-QIT-TOF/MS.
  • Fig. S7. Measuring PRMT8-derived 3Hcholine from 3HDPPC using TLC method.
  • Fig. S8. Methyltransferase and PC phospholipase activities of PRMT8.
  • Fig. S9. Loss of catalytic activities of PRMT8 by replacing serine 120 to alanine.
  • Table S1. Primers used for qPCR quantification of mRNA.
  • Legend for movie S1
  • References (47–50)

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). Behavior of mice in a novel environment.

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