Science Advances

Supplementary Materials

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  • Fig. S1. Additional analyses on TIE2 nuclear expression and glioma radioresistance.
  • Fig. S2. TIE2 nuclear translocation signal.
  • Fig. S3. ANG1 regulates TIE2 nuclear translocation.
  • Fig. S4. S582 and S586 may modulate TIE2 nuclear translocation.
  • Fig. S5. Additional analysis on nuclear TIE2 binding γH2AX complexes.
  • Fig. S6. Additional analysis of the role of nuclear TIE2 in the regulation of DNA repair via NHEJ (Hind III).
  • Fig. S7. Additional analysis of the role of nuclear TIE2 in the regulation of DNA repair via NHEJ (I-Sce I).
  • Fig. S8. Analysis of the relation of Tie2 expression and cell cycle.
  • Fig. S9. Kinase activity of TIE2 is required for TIE2-mediated NHEJ repair.
  • Fig. S10. Nuclear TIE2 is not involved in DNA repair via HR.
  • Fig. S11. Additional analyses on the TIE2-mediated phosphorylation of the conserved Tyr51 residue in H4.
  • Fig. S12. Additional analysis on TIE2/H4pY51 complexes in TIE2-negative cells.
  • Fig. S13. Additional analysis on H4Y51 reader.
  • Fig. S14. Additional analysis on TIE2/ABL1 complexes upon ANG1 or IR.
  • Fig. S15. Additional analyses on nuclear TIE2/DNA repair complexes.
  • Fig. S16. Additional analysis on TIE2/ABL1 axes in NHEJ repair.
  • Table S1. List of siRNA sequences used for this study.
  • Table S2. List of primer sequences.
  • Table S3. List of antibodies used for this study.

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