Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. Expression profile of 15 genes enriched in immune-privileged organs.
  • Fig. S2. Immunostaining of SALM5 in normal mouse brain sections by different mSALM5 antibodies.
  • Fig. S3. Expression of SALM5 protein in mouse tissues.
  • Fig. S4. Effect of SALM5 mAb on LPS-induced systemic inflammation.
  • Fig. S5. CDS screening of a library of transmembrane proteins.
  • Fig. S6. Binding of the mouse BTLA and CD160 binding by mHVEM mutants.
  • Fig. S7. Identification of the binding domain on mSALM5 for mSALM mAb.
  • Fig. S8. SALM5 did not directly affect T cell proliferation.
  • Fig. S9. Administration of F(ab′)2 of SALM5 mAb aggravates EAE.
  • Fig. S10. SALM5, but not CD160, inhibits microglia inflammation.
  • Fig. S11. HVEM is highly expressed in resting lymphocytes and microglia.

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